NDLI: Interferon gamma-induced EGF receptor transactivation depends on the level of expression of EGF receptor in epithelial cells

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Cell and Tissue Biology : Volume 2, Issue 4, August 2008

Cell and Tissue Biology : Volume 2, Issue 3, June 2008

Cell and Tissue Biology : Volume 2, Issue 2, April 2008

Cell and Tissue Biology : Volume 2, Issue 1, February 2008

Cell and Tissue Biology : Volume 1

Interferon gamma-induced EGF receptor transactivation depends on the level of expression of EGF receptor in epithelial cells

Content Provider	Springer Nature Link
Author	Gonchar, I. V. Dorosh, V. N. Nikolsky, N. N. Burova, E. B.
Copyright Year	2008
Abstract	Recently, we demonstrated the transactivation of the epidermal growth factor receptor (EGFR) in response to interferon γ (IFNγ) in epidermoid carcinoma A431 cells. It was shown that IFNγ-induced EGFR transactivation is impossible in the some cancer epithelial cells. Here, we hypothesize that IFNγ-dependent EGFR transactivation in these cells correlates to the amount of EGFR on the surface of the cell. To test this suggestion, a line of stably transfected HEK293 cells (HEK293Δ99 cells) expressing a high level of mutant EGFR that lacked 99 C-terminal residues was obtained. Unlike the parent HEK293 cells, which lacked transactivation, HEK293Δ99 cells demonstrated EGFR transactivation in response to IFNγ. In HEK293Δ99 and A431 cells, the time courses of EGFR activation induced by IFNγ have the same pattern. In HEK293Δ99, as in A431 cells, IFNγ-induced EGFR transactivation requires EGFR kinase activity and occurs via an autophosphorylation mechanism. Taken together, these data provide direct evidence for the dependence of IFNγ-induced EGFR transactivation upon EGFR expression level in epithelial cells.
Starting Page	481
Ending Page	485
Page Count	5
File Format	PDF
ISSN	1990519X
Journal	Cell and Tissue Biology
Volume Number	2
Issue Number	5
e-ISSN	19905203
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2008-10-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	epidermal growth factor receptor IFNγ EGFR transactivation tyrosine kinase A431 HEK293 Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology

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Interferon-γ effect on growth regulation of cells with different levels of EGF receptor expression

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Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context

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Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity.

Extracellular Matrix Selectively Modulates the Response of Mammary Epithelial Cells to Different Soluble Signaling Ligands

Interferon gamma-induced EGF receptor transactivation depends on the level of expression of EGF receptor in epithelial cells

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Interferon gamma-induced EGF receptor transactivation depends on the level of expression of EGF receptor in epithelial cells