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| Content Provider | Springer Nature Link |
|---|---|
| Author | Arkadieva, A. V. Mamov, A. A. Popovich, I. G. Anisimov, V. N. Mikhelson, V. M. Spivak, I. M. |
| Copyright Year | 2011 |
| Abstract | It has been shown recently that metformin, the indirect mTOR-kinase inhibitor, significantly increases medium (by 37.8 %) and maximum (by 10.3 %) life span of SHR mice (Anisimov et al., 2008). We obtained fibroblasts from skin of 11-, 16-, 19- and 23-months-old SHR mice treated with metformin since the third and ninth day of life. We studied markers of cellular senescence in these fibroblasts. Significant differences were observed between the average number of senescence-associated heterchromatic foci (SAHF), the average of area nuclei and fluorescence intensity of nucleus after staining for y-H2AX in control and experimental animals. Also, we showed that metformin prevented the accumulation of fibroblasts with large area of nuclei; high activity of senescence-associated P-galactosidase (SA-(3-gal), and high fluorescence intensity after staining for y-H2AX. It appears that accumulation of large quantity of senescence markers within a cell triggers it to enter the aging process. It appears that the increase of “old” cell population above the threshold disrupts the normal function of certain tissues, organs, and finally, the whole organism. It appears that metformin delays the “old” cells accumulation and prolongs the organism youth. |
| Starting Page | 151 |
| Ending Page | 159 |
| Page Count | 9 |
| File Format | |
| ISSN | 1990519X |
| Journal | Cell and Tissue Biology |
| Volume Number | 5 |
| Issue Number | 2 |
| e-ISSN | 19905203 |
| Language | English |
| Publisher | SP MAIK Nauka/Interperiodica |
| Publisher Date | 2011-05-06 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | metformin cellular senescence rapamycin mTOR-kinase geroprotector Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology |
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