NDLI: Remodeling of rat cardiomyocytes after neonatal cryptosporidiosis. I. Change of ratio of isoforms of myosin heavy chains

Please wait, while we are loading the content...

Multipotent mesenchymal stem cells of desquamated endometrium: Isolation, characterization, and application as a feeder layer for maintenance of human embryonic stem cells

Clonal growth and differentiation of mesenchymal stromal cells from rat liver at different stages of embryogenesis

Interaction between the CDX2 transcription factor and DDX5 protein

The number of cells and the cell proliferation in intima of various human arteries

Remodeling of rat cardiomyocytes after neonatal cryptosporidiosis. I. Change of ratio of isoforms of myosin heavy chains

Mechanisms of epithelial sodium channel (ENaC) regulation by cortactin: Involvement of dynamin

The potential role of presenilin 1 in regulation of synaptic function

Neuronal porosome in the rat and cat brain

The position of cleavage furrow in cultured L-929 and CHO cells

Composite materials based on chitosan and montmorillonite: Prospects for use as a matrix for cultivation of stem and regenerative cells

Peculiarities of liver regeneration in Chinese hamster Cricetulus griseus

Cell and Tissue Biology : Volume 5

Cell and Tissue Biology : Volume 4

Cell and Tissue Biology : Volume 3

Cell and Tissue Biology : Volume 2

Cell and Tissue Biology : Volume 1

Remodeling of rat cardiomyocytes after neonatal cryptosporidiosis. I. Change of ratio of isoforms of myosin heavy chains

Content Provider	Springer Nature Link
Author	Anatskaya, O. V. Matveev, I. V. Sidorenko, N. V. Kharchenko, M. V. Kropotov, A. V. Vigradov, A. E.
Copyright Year	2012
Abstract	Diseases of the human cardiovascular system are the main cause of death in developed countries. Therefore, searching for new risk factors thereof is of particular interest. Upon comparing epidemiological data with data of transcriptome of cardiomyocytes and comparative physiology of vertebrate ontogenesis, we have come to the conclusion that one such factor may be gastroenteritis. This disease includes at once several stimuli able to cause functional and metabolic alterations in the heart: tachycardia, hormonal and ionic misbalance, and outflow of resources from the cardiovascular system. Using the model of rat neonatal gastroenteritis caused by the widespread human and animal enteropathogen Cryptosporidium parvum (Apicomplexa, Sporozoa), we studied the change of expression of α- and β-myosin heavy chains after the developed cryptosporidiosis. Online data obtained by methods of immunocytochemistry, quantitative morphometry, and polymerase chain reaction not only have confirmed our suggestion, but also have shown that moderate 4-day-long cryptosporidiosis is sufficient for producing a significant (1.7- to 4.5-fold) shift in the ratio of myosin isoforms toward the β-isoform beta at the level of mRNA and at the level of protein (2.5–6 times). The reciprocity of the changes, as well as their clear similarity at the level of mRNA and of protein, indicates that the cryptosporidial gastroenteritis involves all the main chains of a complex network of regulation of expression of the myosin heavy chains. A shift of the ratio of myosin isoforms toward the β-isoform that has an ATPase activity several times lower than the α-isoform is the commonly accepted indicator of human heart failure; therefore, the cryptosporidial gastroenteritis can be considered a novel risk factor for decrease of the heart’s contractile ability. Our data may be of interest for clinical and preventive medicine.
Starting Page	40
Ending Page	51
Page Count	12
File Format	PDF
ISSN	1990519X
Journal	Cell and Tissue Biology
Volume Number	6
Issue Number	1
e-ISSN	19905203
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2012-02-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	cardiomyocytes myosin heavy chains expression real-time PCR neonatal gastroenteritis mRNA Cryptosporidium parvum cardiovascular diseases contractile capability Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Remodeling of rat cardiomyocytes after neonatal cryptosporidiosis. II. Deformation, excessive polyploidization, and HIF-1α overexpression

Changes in the heart of neonatal rats after cryptosporidial gastroenteritis of different degrees of severity

The threshold response of neonatal rat cardiomyocytes to gradual enhancement of cryptosporidial invasion

Quantification by real-time PCR of developmental and adult myosin mRNA in rat muscles.

Early remodeling of rat cardiac muscle induced by swimming training

CRYPTOSPORIDIOSIS IN PEDIATRIC PATIENTS

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms

Contractile properties of motor units and expression of myosin heavy chain isoforms in rat fast-type muscle after volitional weight-lifting training.

Renal Transplantli Bir Hastada Cryptosporidium parvum Gastroenteriti.

Remodeling of rat cardiomyocytes after neonatal cryptosporidiosis. I. Change of ratio of isoforms of myosin heavy chains

Similar Documents

Remodeling of rat cardiomyocytes after neonatal cryptosporidiosis. II. Deformation, excessive polyploidization, and HIF-1α overexpression

Changes in the heart of neonatal rats after cryptosporidial gastroenteritis of different degrees of severity

The threshold response of neonatal rat cardiomyocytes to gradual enhancement of cryptosporidial invasion

Quantification by real-time PCR of developmental and adult myosin mRNA in rat muscles.

Early remodeling of rat cardiac muscle induced by swimming training

CRYPTOSPORIDIOSIS IN PEDIATRIC PATIENTS

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms

Contractile properties of motor units and expression of myosin heavy chain isoforms in rat fast-type muscle after volitional weight-lifting training.

Renal Transplantli Bir Hastada Cryptosporidium parvum Gastroenteriti.

Remodeling of rat cardiomyocytes after neonatal cryptosporidiosis. I. Change of ratio of isoforms of myosin heavy chains