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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cha, Woou Beissinger, Richard L. |
| Copyright Year | 2001 |
| Abstract | The shear-induced particle diffusivity in the red blood cell suspensions was evaluated based on the flow model and experimental results in a rectangular flow chamber. The effective diffusivity (D$_{e}$) of solute in the particle suspensions is equal to the stationary diffusivity (D$_{s}$) of the solute plus the shear-induced particle diffusivity (D$_{p}$). The effective diffusivity (D$_{e}$) of bovine serum albumin (BSA) in the red blood cell (RBC) ghost suspensions was determined under diffusion-limited conditions using a total internal reflection fluorescence (TIRF) method as a function of suspended RBC ghost volume fractions (0.05-0.7) and shear rates (200-1,000 s,$^{-1}$). The stationary diffusivity (D$_{s}$) of BSA in RBC ghost suspensions was calculated by Meredith and Tobias model. Therefore the shear-induced particle diffusivity undergoing laminar shear flow can be evaluated. The shear-induced RBC ghost diffusivity was ranged from 0.35xl0$^{-7}$ to 21.2xl0$^{-7}$ cm$^{2}$/s and it increased with increasing shear rate. Also the shear-induced RBC ghost diffusivity increased as a particle volume fraction increased as well, up to a particle volume fraction of 0.45. However, for RBC ghost volume fractions above 0.45, the shear-induced particle diffusivity decreased with increasing particle volume fraction. The shear-induced particle diffusivity in RBC ghost suspensions is a function of a particle Peclet number (or shear rate) and particle volume fractions. The dimensionless particle diffusivity (D$^{ρ}$/a$^{2}$γ) was investigated as a function of particle volume fraction and these results are in good agreement with the literature values. |
| Starting Page | 479 |
| Ending Page | 485 |
| Page Count | 7 |
| File Format | |
| ISSN | 02561115 |
| Journal | Korean Journal of Chemical Engineering |
| Volume Number | 18 |
| Issue Number | 4 |
| e-ISSN | 19757220 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2001-01-01 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Shear-Induced Particle Diffusivity Effective Diffusivity Suspension Red Blood Cell Ghost Particle Motion Industrial Chemistry/Chemical Engineering Catalysis Materials Science Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Chemical Engineering |
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