NDLI: Phase behavior of water-insoluble simvastatin drug in supercritical mixtures of chlorodifluoromethane and carbon dioxide

Content Provider	Springer Nature Link
Author	Oh, Dong Joon Lee, Byung Chul Hwang, Sung Joo
Copyright Year	2006
Abstract	Phase behavior data are presented for simvastatin, a water-insoluble drug, in supercritical solvent mixtures of chlorodifluoromethane (CHClF$_{2}$) and carbon dioxide (CO$_{2}$). The solubilities of the simvastatin drug in the solvent mixtures of CHClF$_{2}$ and CO$_{2}$ were determined by measuring the cloud point pressures using a variable-volume view cell apparatus as functions of temperature, solvent composition, and amount of the drug loaded into the solution. The cloud point pressure increased with increasing the system temperature. As the CHClF$_{2}$ composition in the solvent mixture increased, the cloud point pressure at a fixed temperature decreased. Addition of CHClF$_{2}$ to CO$_{2}$ caused an increase of the dissolving power of the mixed solvent for the simvastatin drug due to the increase of the solvent polarity. CHClF$_{2}$ acted as a solvent for simvastatin, while CO$_{2}$ acted as an anti-solvent. The cloud point pressure increased as the amount of the simvastatin drug in the solvent mixture increased. Consequently, the solubility of the simvastatin drug in the solvent mixture of CHClF$_{2}$ and CO$_{2}$ decreased with increasing the CO$_{2}$ content in the solvent mixture as well as with increasing the system temperature.
Starting Page	1009
Ending Page	1015
Page Count	7
File Format	PDF
ISSN	02561115
Journal	Korean Journal of Chemical Engineering
Volume Number	23
Issue Number	6
e-ISSN	19757220
Language	English
Publisher	Springer US
Publisher Date	2006-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Simvastatin Water-insoluble Drug Solubility Supercritical Fluid Carbon Dioxide Chlorodifluoromethane Cloud Point Pressure Industrial Chemistry/Chemical Engineering Catalysis Materials Science Biotechnology
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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