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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kang, Hyung Sub Park, Hye Min Go, Hyeon Kyu Kim, Shang Jin Kim, Jin Shang Kim, Seong Jong Kim, Gi Beum |
| Copyright Year | 2012 |
| Abstract | The objective of this study was to scrutinize the involvement of nitric oxide (NO) and the diagnosis of blood in ARDS in a rat model determined by the sequential exposure to lipopolysaccharide (LPS). Also, the present study was designed to evaluate the effects of taurine and dexamethasone on ARDS induced by LPS. Measurements of nitrite/nitrate were elevated in BAL of LPS challenged rats, indicative of an induction of the NO synthase. Taurine and dexamethasone abrogated the extent of endotoxin-induced ARDS, as evidenced by the decreases BAL nitrate/nitrite, BALF protein and lung pathology. T+L+D-group had higher PaO$_{2}$ and lower PaCO$_{2}$ values than L-group and T+Lgroup. But, ionized Ca$^{2+}$ and Mg$^{2+}$ both were not shown significant change. Also, T+L and T+L+D-group showed significant increase compared with L-group, but for the other side no significant difference was seen between T+L and T+L+D group. We suggest that taurine and dexamethasone may be a drug of choice for preventing ARDS. |
| Starting Page | 1591 |
| Ending Page | 1596 |
| Page Count | 6 |
| File Format | |
| ISSN | 02561115 |
| Journal | Korean Journal of Chemical Engineering |
| Volume Number | 29 |
| Issue Number | 11 |
| e-ISSN | 19757220 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-05-12 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Acute Respiratory Distress Syndrome (ARDS) Lung Injury Lipopolysaccharide (LPS) Taurine Dexamethasone Nitric Oxide (NO) Materials Science Industrial Chemistry/Chemical Engineering Biotechnology Catalysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Chemical Engineering |
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