NDLI: Conjugated linoleic acid and oxidative stress

Content Provider	Springer Nature Link
Author	Banni, Sebastia Angioni, Elisabetta Contini, Maria Stefania Carta, Gianfranca Casu, Viviana Iengo, Giorgio Amedeo Melis, Maria Paola Deiana, Monica Dessì, Maria Assunta Corongiu, Francesco P.
Copyright Year	1998
Abstract	At the present time, conjugated linoleic acid (CLA) is the subject of a growing number of studies since it has been demonstrated to possess anticarcinogenic and antiatherogenic activities in experimental animal models and to increase in some pathological states in humans. In both situations, CLA has been claimed to be involved in oxidative stress, as an antioxidant in the first case and as a primary product of a free-radical attack on polyunsaturated fatty acids (PUFA) in the other. The controversial results are due mostly to a lack of a suitable methodology because the presence of conjugated dienes (CD) in lipid moiety has been taken for years as evidence of lipid peroxidation due to the occurrence of this structure in fatty acid hydroperoxides. We have recently developed a new methodology that consists of the extraction of fatty acids, including CD fatty acid hydroperoxides, by mild saponification and their separation and identification by high-performance liquid chromatography with diode array detector. Fatty acid analyses of liver homogenate, oxidized in vitro either with Fe-ADP or t-butyl hydroperoxide (t-ButylHP), of lamb and rats fed CLA at levels known to prevent carcinogenesis, showed that CLA and its metabolites steadily decreased during oxidative stress and that they are more prone to oxidation than their corresponding methylene-interrupted fatty acids. No significant antioxidant effect of CLA was detected in any model tested. However, CD fatty acid hydroperoxides increased in the t-ButylHP model but not in the Fe-ADP model, owing probably to the degradation of CD fatty acid hydroperoxides induced by this oxidative agent. In conclusion, CLA and its metabolites seem to behave, under oxidative stress, as regular PUFA. Thus, it is highly unlikely that the peculiar effects of CLA are directly related to interference in lipoperoxidative processes.
Starting Page	261
Ending Page	267
Page Count	7
File Format	PDF
ISSN	0003021X
Journal	Journal of the American Oil Chemists' Society
Volume Number	75
Issue Number	2
e-ISSN	15589331
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Conjugated dienes conjugated linoleic acid diode array detector HPLC hydroperoxides oxidative stress second derivative UV spectrophotometry Industrial Chemistry/Chemical Engineering Analytical Chemistry Chemistry/Food Science Biotechnology Biomaterials Agriculture
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Chemical Engineering

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