NDLI: Partial prevention of hepatic lipid alterations in nude mice by neonatal thymulin gene therapy

Content Provider	Springer Nature Link
Author	García de Bravo, Margarita M. Polo, Mónica P. Reggiani, Paula C. Rimoldi, Omar J. Dardenne, Mireille Goya, Rodolfo G.
Copyright Year	2006
Abstract	During adult life athymic (nude) male mice display not only a severe T-cell-related immunodeficiency but also endocrine imbalances and a moderate hyperglycemia. We studied the impact of congential athymia on hepatic lipid composition and also assessed the ability of neonatal thymulin gene therapy to prevent the effects of athymia. We constructed a recombinant adenoviral vector, RAd-metFTS, expression a synthetic DNA sequence encoding met-FTS, an analog of the thymic peptide facteur thymique sérique (FTS), whose Zn-bound biologically active form is known as thymulin. On postnatal day 1–2 homozygous (nu/nu) nude and heterozygous (nu/+) mice were injected with 10$^{8}$ pfu of RAd-metFTS or RAd-βgal (control vector) intramuscularly. The animals were processed at 52 d of age. Serum thymulin, glycemia, hepatic phospholipid FA compostion and free and esterified cholesterol were determined. Adult homozygous male nudes were significantly (P<0.01) hyperglycemic when compared with their heterozygous counterparts (2.04 vs. 1.40 g/L, respectively). The relative percentage of 16∶0, 18∶1n−9, and 18∶1n−7 FA was lower, whereas that of 18∶0, 20∶4n−6, and 22∶6n−3 FA was higher, in hepatic phospholipid (PL) of nu/nu animals as compared with their nu/+ counterparts. Some of these alterations, such as that in the relative content of 22∶6n−3 in liver PL and the unsaturation index, were completely or partially prevented by neonatal thymulin gene therapy. We conclude that the thymus influences lipid metabolism and that thymulin is involved in this modulatory activity.
Starting Page	753
Ending Page	757
Page Count	5
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	41
Issue Number	8
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nutrition Bioorganic Chemistry Medicinal Chemistry Medical Biochemistry Biochemistry Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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