NDLI: Abnormalities in the Metabolism of Fatty Acids and Triacylglycerols in the Liver of the Goto-Kakizaki Rat: A Model for Non-Obese Type 2 Diabetes

Content Provider	Springer Nature Link
Author	Karahashi, Minako Hirata Hanta, Yuko Kawabata, Kohei Tsutsumi, Daisuke Kametani, Misaki Takamatsu, Nanako Sakamoto, Takeshi Yamazaki, Tohru Asa, Satoshi Mitsumoto, Atsushi Kawashima, Yoichi Kudo, Naomi
Copyright Year	2016
Abstract	The Goto-Kakizaki (GK) rat is widely used as an animal model for spontaneous-onset type 2 diabetes without obesity; nevertheless, little information is available on the metabolism of fatty acids and triacylglycerols (TAG) in their livers. We investigated the mechanisms underlying the alterations in the metabolism of fatty acids and TAG in their livers, in comparison with Zucker (fa/fa) rats, which are obese and insulin resistant. Lipid profiles, the expression of genes for enzymes and proteins related to the metabolism of fatty acid and TAG, de novo synthesis of fatty acids and TAG in vivo, fatty acid synthase activity in vitro, fatty acid oxidation in liver slices, and very-low-density-lipoprotein (VLDL)-TAG secretion in vivo were estimated. Our results revealed that (1) the TAG accumulation was moderate, (2) the de novo fatty acid synthesis was increased by upregulation of fatty acid synthase in a post-transcriptional manner, (3) fatty acid oxidation was also augmented through the induction of carnitine palmitoyltransferase 1a, and (4) the secretion rate of VLDL-TAG remained unchanged in the livers of GK rats. These results suggest that, despite the fact that GK rats exhibit non-obese type 2 diabetes, the upregulation of de novo lipogenesis is largely compensated by the upregulation of fatty acid oxidation, resulting in only moderate increase in TAG accumulation in the liver.
Starting Page	955
Ending Page	971
Page Count	17
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	51
Issue Number	8
e-ISSN	15589307
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-07-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fatty acid synthesis Triacylglycerol metabolism Fatty acid β-oxidation Liver Non-obese diabetes Goto-Kakizaki rat Lipidology Neurochemistry Medical Biochemistry Nutrition Medicinal Chemistry Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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