NDLI: $^{1}$H and $^{13}$C NMR characterization and stereochemical assignments of bile acids in aqueous media

Content Provider	Springer Nature Link
Author	Ijare, Omkar B. Somashekar, B. S. Jadegoud, Y. Nagana Gowda, G. A.
Copyright Year	2005
Abstract	The unconjugated bile acids cholic acid, deoxycholic acid, and chenodeoxycholic acid; their glycine and taurine conjugated glycocholic acid, glycodeoxycholic acid, glycochenodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, and taurochenodeoxycholic acid; and a taurine conjugated ursodeoxycholic acid, tauroursodeoxycholic acid, were characterized through $^{1}$H and $^{13}$C NMR in aqueous media under the physiological pH region (7.4±0.1). Assignments of $^{1}$H and $^{13}$C signals of all the bile acids were made using a combination of several one- and two-dimensional, homonuclear ($^{1}$H−$^{1}$H) and heteronuclear ($^{1}$H−$^{13}$C) correlations as well as spectral editing NMR methods. Stereochemical assignment of the five-membered ring of the bile acids is reported here for the first time. The complete characterization of various bile acids in aqueous media presented here may have implications in the study of the pathophysiology of biliary diseases through human biliary fluids using NMR spectroscopy.
Starting Page	1031
Ending Page	1041
Page Count	11
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	40
Issue Number	10
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nutrition Bioorganic Chemistry Medicinal Chemistry Medical Biochemistry Biochemistry Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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