NDLI: Dietary Free Oleic and Linoleic Acid Enhances Neutrophil Function and Modulates the Inflammatory Response in Rats

Content Provider	Springer Nature Link
Author	Rodrigues, Hosana Gomes Vilo, Marco Aurélio Ramirez Magdalon, Juliana Fujiwara, Haroldo Cavalcanti, Danielle M. H. Farsky, Sandra H. P. Calder, Philip C. Hatanaka, Elaine Curi, Rui
Copyright Year	2010
Abstract	The high ingestion of oleic (OLA) and linoleic (LNA) acids by Western populations, the presence of inflammatory diseases in these populations, and the importance of neutrophils in the inflammatory process led us to investigate the effects of oral ingestion of unesterified OLA and LNA on rat neutrophil function. Pure OLA and LNA were administered by gavage over 10 days. The doses used (0.11, 0.22 and 0.44 g/kg of body weight) were based on the Western consumption of OLA and LNA. Neither fatty acid affected food, calorie or water intake. The fatty acids were not toxic to neutrophils as evaluated by cytometry using propidium iodide (membrane integrity and DNA fragmentation). Neutrophil migration in response to intraperitoneal injection of glycogen and in the air pouch assay, was elevated after administration of either OLA or LNA. This effect was associated with enhancement of rolling and increased release of the chemokine CINC-2αβ. Both fatty acids elevated l-selectin expression, whereas no effect on β$_{2}$-integrin expression was observed, as evaluated by flow cytometry. LNA increased the production of proinflammatory cytokines (IL-1β and CINC-2αβ) by neutrophils after 4 h in culture and both fatty acids decreased the release of the same cytokines after 18 h. In conclusion, OLA and LNA modulate several functions of neutrophils and can influence the inflammatory process.
Starting Page	809
Ending Page	819
Page Count	11
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	45
Issue Number	9
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-08-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neutrophil migration Inflammation Adhesion molecules Cytokines Oleic acid and linoleic acid Microbial Genetics and Genomics Medicinal Chemistry Nutrition Medical Biochemistry Neurochemistry Lipidology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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