NDLI: Phase Behavior of Ascorbyl Palmitate Coagels Loaded with Oligonucleotides as a New Carrier for Vaccine Adjuvants

Content Provider	Springer Nature Link
Author	Ullio Gamboa, Gabriela V. Benedini, Lucia A. Schulz, Pablo C. Allemandi, Daniel A.
Copyright Year	2016
Abstract	In this work, the phase behavior variations of an ascorbyl palmitate (Asc$_{16}$) system in aqueous solution were analyzed when immunologically active hydrophilic compounds (CpG and OVA) were introduced. This study was carried out through optical polarizing microscopy (OPM) and differential scanning calorimetry (DSC) at different temperatures and over a broad range of concentrations. The combination of both techniques allowed the determination of a complete phase diagram which was compared with those built for Asc$_{16}$-water system and it was demonstrated that fixed concentrations of hydrophilic compounds (300 and 24 µg/g for CpG-ODN and OVA respectively) generate two lamellar liquid crystals, a cubic liquid crystal phase, and also other aggregates. However, no changes were observed in the phase diagram in terms of formation of new mesophases. The aqueous phase behavior was also studied as a function of surfactant and temperature. DSC and Fourier transform infrared spectroscopy (FT-IR) measurements show differences in the free water and mainly in the secondary hydration layer, which confirm that the studied compounds are situated in the aqueous domain. The construction and analysis of Asc$_{16}$ phase diagrams with a fixed concentration of CpG-ODN/OVA allows the comprehension of Asc$_{16}$ phase behavior and could be easily adapted to other concentrations. Moreover, these findings could be extrapolated to other hydrophilic substances in aqueous solution introduced in liquid crystal phases since they follow a similar behavior as those reported in the literature.
Starting Page	747
Ending Page	757
Page Count	11
File Format	PDF
ISSN	10973958
Journal	Journal of Surfactants and Detergents
Volume Number	19
Issue Number	4
e-ISSN	15589293
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-04-26
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ascorbyl palmitate Liquid crystals Oligonucleotides Phase diagrams Water behavior Industrial Chemistry/Chemical Engineering Waste Water Technology Water Pollution Control Water Management Aquatic Pollution Surfaces and Interfaces, Thin Films Polymer Sciences Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Surfaces, Coatings and Films Physical and Theoretical Chemistry Chemical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Phase behavior of a fragrance compound system: Water/phenethyl alcohol/laureth 4/glycerol

Alkyl polyglucosides as hydrotropes

Robust Flash Calculation Algorithm for Microemulsion Phase Behavior

Physicochemical Properties and Phase Behavior of Didecyldimethylammonium Chloride/Alkyl Polyglycoside Surfactant Mixtures

Hydrophobic polymers for liquid cleaning formulations

Phase and Rheological Behavior of Cetyldimethylbenzylammonium Salicylate (CDBAS) and Water

Phase behavior of laundry surfactants in polar solvents

Phase and Rheological Properties of a Curcumin-Encapsulated Cubic Liquid Crystal

Production of Palm-Based Esteramine Through Heterogeneous Catalysis

Phase Behavior of Ascorbyl Palmitate Coagels Loaded with Oligonucleotides as a New Carrier for Vaccine Adjuvants

Similar Documents

Phase behavior of a fragrance compound system: Water/phenethyl alcohol/laureth 4/glycerol

Alkyl polyglucosides as hydrotropes

Robust Flash Calculation Algorithm for Microemulsion Phase Behavior

Physicochemical Properties and Phase Behavior of Didecyldimethylammonium Chloride/Alkyl Polyglycoside Surfactant Mixtures

Hydrophobic polymers for liquid cleaning formulations

Phase and Rheological Behavior of Cetyldimethylbenzylammonium Salicylate (CDBAS) and Water

Phase behavior of laundry surfactants in polar solvents

Phase and Rheological Properties of a Curcumin-Encapsulated Cubic Liquid Crystal

Production of Palm-Based Esteramine Through Heterogeneous Catalysis

Phase Behavior of Ascorbyl Palmitate Coagels Loaded with Oligonucleotides as a New Carrier for Vaccine Adjuvants