NDLI: Role of Ethylene Oxide and Propylene Oxide Groups of Pluronics in Binding of Fatty Acid to Pluronics in Microemulsions

Content Provider	Springer Nature Link
Author	James Smith, Monica A. Shekhawat, Dushyant Cheung, Sally Moudgil, Brij M. Shah, Dinesh O.
Copyright Year	2008
Abstract	We investigated the drug and fatty acid binding capacity of Pluronic-based microemulsions through simple turbidity experiments. Pluronic-based oil-in-water microemulsions of various compositions were synthesized and titrated to turbidity with concentrated amitriptyline, an antidepressant drug. The BASF Pluronic grid was used to select two series of Pluronic surfactants: (1) those having the same number of ethylene oxide (EO) groups, with an increasing number of propylene oxide (PO) groups and (2) those having the same number of propylene oxide groups with an increasing number of ethylene oxide groups. We observed that the binding of sodium caprylate fatty acid and amitriptyline drug increases with increasing hydrophobicity (i.e., increasing number of PO groups). This is attributed to the greater number of binding sites for the sodium caprylate, which results in more charge on the microemulsion, subsequently leading to increased drug binding. We also determined that when the number of PO groups was held fixed and the number of EO groups was increased, there is no direct correlation to the binding behavior of fatty acid and drug. This is due to the fact that the hydrophilic groups (EO) do not play a direct role in the binding of fatty acid molecules. In fact, when there are a significantly large number of EO groups present, they can act to inhibit binding of fatty acid and hence, drug, to the microemulsion.
Starting Page	237
Ending Page	242
Page Count	6
File Format	PDF
ISSN	10973958
Journal	Journal of Surfactants and Detergents
Volume Number	11
Issue Number	3
e-ISSN	15589293
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-07-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Oil-in-water microemulsion Pluronic surfactants Ethylene oxide Propylene oxide Amitriptyline Sodium caprylate Turbidity Binding capacity Physical Chemistry Polymer Sciences Surfaces and Interfaces, Thin Films Waste Water Technology Water Pollution Control Water Management Aquatic Pollution Industrial Chemistry/Chemical Engineering
Content Type	Text
Resource Type	Article
Subject	Surfaces, Coatings and Films Physical and Theoretical Chemistry Chemical Engineering

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