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An inhibitor of serine proteases, serpinb1a, modulates differentiation of PC12 cells but not cultured neurons

Content Provider	Springer Nature Link
Author	Salozhin, S. V. Borodiva, A. A. Kvichanskii, A. A. Mikhailova, T. V. Spivak, Yu. S. Bolshakov, A. P.
Copyright Year	2017
Abstract	It was shown that serpinb1a is expressed during differentiation of PC12 cells induced by nerve growth factor (NGF). Here, we found that overexpression of serpinb1a in PC12 cells weakly but significantly increases PC12 survival during staurosporine-induced apoptosis. Immunoprecipitation of serpinb1a after its overexpression in PC12 showed that this protein interacts with active caspase-3 in both resting cells and cells that were stimulated by staurosporine. NGF-induced PC12 differentiation resulted in the formation of outgrowths and a considerable increase in caspase-3 activity in 24 h after the beginning of NGF treatment. This increase in the activity of caspase-3 lasted for at least 48 h. Overexpression of serpinb1a in PC12 cells suppressed the growth of neurites during NGF-induced differentiation; this effect was observed only at 48 h. Experiments performed with primary cultures of neocortical and hippocampal neurons showed that serpinb1a overexpression results in relatively weak changes in morphology: serpinb1a decreased the number of secondary dendrites in the cortical and average length of secondary dendrites in hippocampal neurons. The results of the experiments suggests that serpinb1a may interact with caspase-3 and influence the differentiation of PC12 cells but not neuronal cells.
Starting Page	23
Ending Page	30
Page Count	8
File Format	PDF
ISSN	18197124
Journal	Neurochemical Journal
Volume Number	11
Issue Number	1
e-ISSN	18197132
Language	English
Publisher	Pleiades Publishing
Publisher Date	2017-03-25
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	pheochromocytoma PC12 neuronal culture caspase-3 serpinb1a nerve growth factor Neurosciences
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry Cellular and Molecular Neuroscience

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