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| Content Provider | Springer Nature Link |
|---|---|
| Author | Onufriev, M. V. Semeva, T. P. Volkova, E. P. Sergun’kina, M. A. Yakovlev, A. A. Zakharova, N. M. Gulyaeva, N. V. |
| Copyright Year | 2016 |
| Abstract | In this study we described the seasonal profile of the actin and Cdk5 levels in different brain structures of Yakut long-tailed ground squirrels (Spermophilus undulatus) during their annual cycle. Experiments were performed with adult Yakut ground squirrels, both male and female, weighing 600–800 g (n = 35) at different stages of their annual cycle, viz., in the summer, the period of the maximum activity of the animals; in the autumn, during preparation for hibernation; in the winter, during hibernation; in the spring, at the exit of the animals from the hibernating state. Our results indicate that actin mRNA increased by 1.9 times (p = 0.0001) in the frontal cortex, the hippocampus, and the caudal brainstem during hibernation. In the brainstem, a significant increase in actin mRNA started to develop in autumn, in normothermic animals at the stage of their preparation for hibernation (p = 0.0078). At the exit of animals from the torpid state, the level of hippocampal expression decreased significantly by 4.5 times; in the cortex and brainstem it decreased to the level of summer animals. In contrast, the dynamics in the cerebellum had opposite direction: actin mRNA level decreased significantly during the preparation for hibernation (p = 0.037), remained low in torpid animals (p = 0.051), and increased after awakening. The changes in the total protein level were observed only in the hippocampus, along with increased expression of Cdk5 mRNA during hibernation (p = 0.003) and at the exit from it (p = 0.001). Detected differences in the seasonal metabolic profile of cytoskeleton proteins in the hippocampus of Yakut long-tailed ground squirrels support a substantial structural plasticity of this brain structure during the hibernation cycle that was described previously in morphological and biochemical studies. |
| Starting Page | 98 |
| Ending Page | 105 |
| Page Count | 8 |
| File Format | |
| ISSN | 18197124 |
| Journal | Neurochemical Journal |
| Volume Number | 10 |
| Issue Number | 2 |
| e-ISSN | 18197132 |
| Language | English |
| Publisher | Pleiades Publishing |
| Publisher Date | 2016-06-16 |
| Publisher Place | Moscow |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | hibernation Yakut long-tailed ground squirrels seasonal changes actin mRNA expression Cdk5 mRNA expression total protein level Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Biochemistry Cellular and Molecular Neuroscience |
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