NDLI: Development of pentylenetetrazole kindling in rats is associated with an increase in hippocampal doublecortin expression

Please wait, while we are loading the content...

Development of pentylenetetrazole kindling in rats is associated with an increase in hippocampal doublecortin expression

Content Provider	Springer Nature Link
Author	Aniol, V. A. Yakovlev, A. A. Stepanichev, M. Yu. Lazareva, N. A. Gulyaeva, N. V.
Copyright Year	2009
Abstract	Doublecortin is a 50 kDa protein normally expressed in neurons at early stages of their differentiation. In this study, we investigated the doublecortin expression in rat hippocampus during chronic pentylenetetrazole administration (kindling). Rats were decapitated after the 1st, 3rd, 5th, and 13th injection of the chemoconvulsant at a subconvulsive dose; doublecortin levels were assessed using Western-blot analysis. Antibodies to doublecortin stained two proteins with molecular weights of 50 and 70 kDa. Doublecortin expression increased after 13 injections of pentylenetetrazole, which indicates intensification of neurogenesis in the hippocampus of rats with increased seizure readiness. The 70 kDa proteins were found in both neocortex and hippocampus; changes in their expression did not correlate with doublecortin expression.
Starting Page	179
Ending Page	183
Page Count	5
File Format	PDF
ISSN	18197124
Journal	Neurochemical Journal
Volume Number	3
Issue Number	3
e-ISSN	18197132
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2009-09-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	hippocampus neurogenesis doublecortin pentylenetetrazole epilepsy Neurosciences
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in