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The levels of monoamines and their metabolites in the brain structures of rats with an experimental anxiodepressive state induced by administration of an inhibitor of dipeptidyl peptidase 4 in the early postnatal period

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The levels of monoamines and their metabolites in the brain structures of rats with an experimental anxiodepressive state induced by administration of an inhibitor of dipeptidyl peptidase 4 in the early postnatal period

Content Provider	Springer Nature Link
Author	Kushnareva, E. Yu. Krupina, N. A. Khlebnikova, N. N. Kudrin, V. S. Zolotov, N. N. Kryzhavskii, G. N.
Copyright Year	2012
Abstract	In a model of an experimental anxiodepressive state induced by postnatal administration of an inhibitor of dipeptidyl peptidase 4 (DPP-4), we studied peculiarities of the turnover of dopamine (DA), noradrenaline (NA), and serotonin (5-HT) in the brain structures of rats at ages of 1, 3, and 7 months. In males, the major changes in the functional activity of the DA system, which are related to a decrease in DA turnover according to the HVA/DA ratio, were observed in the striatum. In males at an age of 7 months, we found an increase in the NA level in the hypothalamus. In females, changes in the state of the DA system included a decrease in the level of DA and its metabolites in the nucleus accumbens (1 and 3 months), the level of DOPAC in the hypothalamus (3 months), and the level of DA in the striatum (7 months). At all ages, in the hippocampus of females, we found an increase in the functional activity of 5-HT, according to the 5-HIAA/5-HT and 5-HIAA level. In the frontal cortex of females at an age of 3 months we found a decrease in the 5-HIAA/5-HT ratio and an increase in the DOPAC/DA ratio, while at the age of 7 months, we observed an increase in 5-HT. These changes in the activity of the central monoaminergic systems may reflect specific features of the functioning of the pathological system of the anxiodepressive state in the CNS that determine the character of the formation and dynamics of emotional behavioral disturbances of male and female rats.
Starting Page	29
Ending Page	37
Page Count	9
File Format	PDF
ISSN	18197124
Journal	Neurochemical Journal
Volume Number	6
Issue Number	1
e-ISSN	18197132
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2012-03-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	model anxiodepressive state inhibitor of dipeptidyl peptidase 4 rats brain monoamines and their metabolites Neurosciences
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry Cellular and Molecular Neuroscience

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