NDLI: In vitro and in vivo evaluation of bone morphogenetic protein-2 (BMP-2) immobilized collagen-coated polyetheretherketone (PEEK)

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In vitro and in vivo evaluation of bone morphogenetic protein-2 (BMP-2) immobilized collagen-coated polyetheretherketone (PEEK)

Content Provider	Springer Nature Link
Author	Du, Ya Wei Zhang, Li Nan Ye, Xin Nie, He Min Hou, Zeng Tao Zeng, Teng Hui Yan, Guo Ping Shang, Peng
Copyright Year	2015
Abstract	Polyetheretherketone (PEEK) is regarded as one of the most potential candidates of biomaterials in spinal implant applications. However, as a bioinert material, PEEK plays a limited role in osteoconduction and osseointegration. In this study, recombinant human bone morphogenetic protein-2 (rhBMP-2) was immobilized onto the surface of collagen-coated PEEK in order to prepare a multi-functional material. After adsorbed onto the PEEK surface by hydrophobic interaction, collagen was cross-linked with N-(3-dimethylaminopropyl)-N′-ethyl carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). EDC/NHS system also contributed to the immobilization of rhBMP-2. Water contact angle tests, XPS and SEM clearly demonstrated the surface changes. ELISA tests quantified the amount of rhBMP-2 immobilized and the release over a period of 30 d. In vitro evaluation proved that the osteogenesis differentiation rate was higher when cells were cultured on modified PEEK discs than on regular ones. In vivo tests were conducted and positive changes of major parameters were presented. This report demonstrates that the rhBMP-2 immobilized method for PEEK modification increase bioactivity in vitro and in vivo, suggesting its practicability in orthopedic and spinal clinical applications.
Starting Page	38
Ending Page	50
Page Count	13
File Format	PDF
ISSN	2095025X
Journal	Frontiers of Materials Science in China
Volume Number	9
Issue Number	1
e-ISSN	20950268
Language	English
Publisher	Higher Education Press
Publisher Date	2015-01-21
Publisher Institution	Chinese Universities
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	polyetheretherketone (PEEK) spinal implantation bone morphogenetic protein-2 (BMP-2) collagen surface modification Materials Science
Content Type	Text
Resource Type	Article
Subject	Materials Science

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