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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tran, Michelle Wang, Chun |
| Copyright Year | 2014 |
| Abstract | Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semisolid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation. |
| Starting Page | 225 |
| Ending Page | 232 |
| Page Count | 8 |
| File Format | |
| ISSN | 20950179 |
| Journal | Frontiers of Chemical Engineering in China |
| Volume Number | 8 |
| Issue Number | 2 |
| e-ISSN | 20950187 |
| Language | English |
| Publisher | Higher Education Press |
| Publisher Date | 2014-05-29 |
| Publisher Institution | Chinese Universities |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | semi-solids polymer excipient controlled release drug delivery Industrial Chemistry/Chemical Engineering Nanotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemical Engineering |
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