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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wang, Lingchong Wu, Hao Chang, Nian Zhang, Kun |
| Copyright Year | 2010 |
| Abstract | Total macromolecule extract was obtained from the soft body of Mactra veneriformis by the coupling techniques of decoction and alcohol precipitation. The extract was deproteinized with an ion exchange column, and resulted in the purifying of the crude polysaccharide fraction. It was found by chemical analysis that the crude polysaccharide part is composed of abundant polysaccharides (> 95%) and few proteins (< 1%). Furthermore, only one type of monosaccharide, glucose, was detected from its hydrolytes by thin-layer chromatography, indicating that the polysaccharides might be analogs of glucosan. The anti-hyperglycemia effects of the crude polysaccharide part were preliminarily investigated using several pharmacological methods in normal and diabetic mice. Animal experimental results showed that the crude polysaccharide fraction exhibited proper glycemia inhibition activity, and 300 mg/kg-weight dose has the optimal effect among all the studied doses. It is concluded that the crude polysaccharide fraction can be explored as a novel health product that possesses potential as an anti-hyperglycemic agent. |
| Starting Page | 238 |
| Ending Page | 244 |
| Page Count | 7 |
| File Format | |
| ISSN | 20950179 |
| Journal | Frontiers of Chemical Engineering in China |
| Volume Number | 5 |
| Issue Number | 2 |
| e-ISSN | 16737474 |
| Language | English |
| Publisher | SP Higher Education Press |
| Publisher Date | 2010-06-03 |
| Publisher Institution | Chinese Universities |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | anti-hyperglycemia Mactra veneriformis polysaccharide monosaccharide composition oral glucose tolerance test Nanotechnology Industrial Chemistry/Chemical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemical Engineering |
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