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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wang, Heyun Feng, Yakai Behl, Marc Lendlein, Andreas Zhao, Haiyang Xiao, Ruofang Lu, Jian Zhang, Li Guo, Jintang |
| Copyright Year | 2011 |
| Abstract | In this paper, a scaffold, which mimics the morphology and mechanical properties of a native blood vessel is reported. The scaffold was prepared by sequential bi-layer electrospinning on a rotating mandrel-type collector. The tubular scaffolds (inner diameter 4 mm, length 3 cm) are composed of a polyurethane (PU) fibrous outer-layer and a gelatin-heparin fibrous inner-layer. They were fabricated by electrospinning technology, which enables control of the composition, structure, and mechanical properties of the scaffolds. The microstructure, fiber morphology and mechanical properties of the scaffolds were examined by means of scanning electron microscopy (SEM) and tensile tests. The PU/gelatinheparin tubular scaffolds have a porous structure. The scaffolds achieved a breaking strength (3.7±0.13 MPa) and an elongation at break (110±8%) that are appropriate for artificial blood vessels. When the scaffolds were immersed in water for 1 h, the breaking strength decreased slightly to 2.2±0.3 MPa, but the elongation at break increased to 145±21%. In platelet adhesion tests the gelatin-heparin fibrous scaffolds showed a significant suppression of platelet adhesion. Heparin was released from the scaffolds at a fairly uniform rate during the period of 2$^{nd}$ day to 9$^{th}$ day. The scaffolds are expected to mimic the complex matrix structure of native arteries, and to have good biocompatibility as an artificial blood vessel owing to the heparin release. |
| Starting Page | 392 |
| Ending Page | 400 |
| Page Count | 9 |
| File Format | |
| ISSN | 20950179 |
| Journal | Frontiers of Chemical Engineering in China |
| Volume Number | 5 |
| Issue Number | 3 |
| e-ISSN | 16737474 |
| Language | English |
| Publisher | SP Higher Education Press |
| Publisher Date | 2011-06-21 |
| Publisher Institution | Chinese Universities |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | electrospinning artificial blood vessels scaffold polyurethane gelatin nanofiber hemocompatibility Industrial Chemistry/Chemical Engineering Nanotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemical Engineering |
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