NDLI: Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

Content Provider	Springer Nature Link
Author	Ernst, A. blet, V. Denkova, E. Blanc, F. Seze, J. Gout, D. Manning, L.
Copyright Year	2015
Abstract	Mental time travel (MTT) entails the ability to mentally travel into autobiographical memory (AM) and episodic future thinking (EFT). While AM and EFT share common phenomenological and cerebral functional properties, distinctive characteristics have been documented in healthy and clinical populations. No report, to our knowledge, has informed on the functional underpinnings of MTT impairment in multiple sclerosis (MS) patients, hence the aim of this work. We studied 22 relapsing-remitting MS patients and 22 matched controls. Participants underwent an AM/EFT assessment using the Autobiographical Interview (Levine et al. 2002), followed by a functional MRI session. The latter consisted in AM and EFT tasks, distinguishing the construction and elaboration phases of events. The results showed impaired performance for AM and EFT in patients, accompanied by increased cerebral activations mostly located in the frontal regions, which extended to the parietal, lateral temporal and posterior regions during AM/EFT tasks, relative to healthy controls. Enhanced brain activations in MS patients were particularly evident during the EFT task and involved the hippocampus, frontal, external temporal, and cingulate regions. The construction phase required greater fronto-parieto-temporal activations in MS patients relative to both healthy controls, and the elaboration phase. Taking together, our results suggested the occurrence of cerebral activation changes in the context of MTT in MS patients, expressed by distinct and common mechanisms for AM and EFT. This study may provide new insights in terms of cerebral activation changes in brain lesion and their application to clinical settings, considering AM/EFT’s central role in everyday life.
Starting Page	296
Ending Page	313
Page Count	18
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	10
Issue Number	1
e-ISSN	19317565
Language	English
Publisher	Springer US
Publisher Date	2015-05-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerebral activation changes Multiple sclerosis Mental time travel Functional MRI Neurosciences Neuroradiology Neuropsychology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Multi-parametric quantitative MRI of normal appearing white matter in multiple sclerosis, and the effect of disease activity on T2

Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study

Chemotherapy-induced amenorrhea: a prospective study of brain activation changes and neurocognitive correlates

Warmer outdoor temperature is associated with task-related increased BOLD activation in patients with multiple sclerosis

Neuroimaging and cognition using functional near infrared spectroscopy (fNIRS) in multiple sclerosis

Increased functional connectivity within memory networks following memory rehabilitation in multiple sclerosis

Cognitive rehabilitation correlates with the functional connectivity of the anterior cingulate cortex in patients with multiple sclerosis

Verum and sham acupuncture exert distinct cerebral activation in pain processing areas: a crossover fMRI investigation in healthy volunteers

Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

Similar Documents

Multi-parametric quantitative MRI of normal appearing white matter in multiple sclerosis, and the effect of disease activity on T2

Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study

Chemotherapy-induced amenorrhea: a prospective study of brain activation changes and neurocognitive correlates

Warmer outdoor temperature is associated with task-related increased BOLD activation in patients with multiple sclerosis

Neuroimaging and cognition using functional near infrared spectroscopy (fNIRS) in multiple sclerosis

Increased functional connectivity within memory networks following memory rehabilitation in multiple sclerosis

Cognitive rehabilitation correlates with the functional connectivity of the anterior cingulate cortex in patients with multiple sclerosis

Verum and sham acupuncture exert distinct cerebral activation in pain processing areas: a crossover fMRI investigation in healthy volunteers

Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients