NDLI: Morphological alterations in amygdalo-hippocampal substructures in narcolepsy patients with cataplexy

Content Provider	Springer Nature Link
Author	Kim, Hosung Suh, Sooyeon Joo, Eun Yeon Hong, Seung Bong
Copyright Year	2015
Abstract	Although the role of hypocretin-mediated amygdalo-hippocampal dysfunction is hypothesized to be linked with narcolepsy, there have been no human MRI studies investigating the relationship between their regional volume and key symptoms of narcolepsy. To investigate the morphological changes of amygdalo-hippocampus and its relationship with clinical features in patients with narcolepsy, point-wise morphometry that allowed for measuring the regional volumes of amygdalo-hippocampus on T1-weighted MRI was applied. Participants were 33 drug-naïve patients and 35 age-/gender-matched controls (mean ± SD: 27 ± 6 years). We compared hippocampal and amygdalar subfields volumes between patients and controls and correlated between volume and clinical and neuropsychological features in patients. Bilateral hippocampal atrophy (183 vertices) was identified mainly located within the CA1 subfield (FDR < 0.05). Significant amygdalar volume reduction was found in the areas of the centromedial (102 vertices) and laterobasal nuclear groups (LB, 35 vertices). There was no volume increase in patients relative to controls (FDR >0.2). After controlling depressive mood, sleep quality, age, and gender, hippocampal CA1 atrophy and amygdalar centromedial atrophy were associated with longer duration of daytime sleepiness and shorter mean REM sleep latency (\|r\| >0.44, p < 0.01). The amygdalar centromedial atrophy was associated with longer duration of cataplexy (\|r\| >0.47, p < 0.005). Subfields atrophy of amygdalo-hippocampus in untreated patients with narcolepsy that was found relative to controls suggests that CA1 of the hippocampus and centromedial area of amygdala are closely related to the severity of narcolepsy and play a crucial role in the circuitry of cataplexy.
Starting Page	984
Ending Page	994
Page Count	11
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	10
Issue Number	4
e-ISSN	19317565
Language	English
Publisher	Springer US
Publisher Date	2015-10-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Narcolepsy Amygdale Hippocampus Surface analysis MRI volumetry Neurosciences Neuroradiology Neuropsychology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Coffee consumption may influence hippocampal volume in young women

Problematic internet use is associated with structural alterations in the brain reward system in females

Grey matter correlates of susceptibility to scams in community-dwelling older adults

Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults

CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer’s pathological cascade

“Small World” architecture in brain connectivity and hippocampal volume in Alzheimer’s disease: a study via graph theory from EEG data

FKBP5 modulates the hippocampal connectivity deficits in depression: a study in twins

Distinct effects of late adulthood cognitive and physical activities on gray matter volume

Structural changes in the hippocampus and amygdala at first episode of psychosis

Morphological alterations in amygdalo-hippocampal substructures in narcolepsy patients with cataplexy

Similar Documents

Coffee consumption may influence hippocampal volume in young women

Problematic internet use is associated with structural alterations in the brain reward system in females

Grey matter correlates of susceptibility to scams in community-dwelling older adults

Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults

CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer’s pathological cascade

“Small World” architecture in brain connectivity and hippocampal volume in Alzheimer’s disease: a study via graph theory from EEG data

FKBP5 modulates the hippocampal connectivity deficits in depression: a study in twins

Distinct effects of late adulthood cognitive and physical activities on gray matter volume

Structural changes in the hippocampus and amygdala at first episode of psychosis

Morphological alterations in amygdalo-hippocampal substructures in narcolepsy patients with cataplexy