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| Content Provider | Springer Nature Link |
|---|---|
| Author | Naito, Eiji Kudo, Daichi Sekine, Shin ichiro Watanabe, Kazuhiro Kobatake, Yui Tamaoki, Naritaka Inden, Masatoshi Iida, Kazuki Ito, Yusuke Hozumi, Isao Shibata, Toshiyuki Maeda, Sadatoshi Kamishina, Hiroaki |
| Copyright Year | 2015 |
| Abstract | Dental pulp cells (DPCs) of various species have been studied for their potentials of differentiation into functional neurons and secretion of neurotrophic factors. In canine, DPCs have only been studied for cell surface markers and differentiation, but there is little direct evidence for therapeutic potentials for neurological disorders. The present study aimed to further characterize canine DPCs (cDPCs), particularly focusing on their neuroregenerative potentials. It was also reported that superparamagnetic iron oxide (SPIO) particles were useful for labeling of MSCs and tracking with magnetic resonance imaging (MRI). Our data suggested that cDPCs hold higher proliferation capacity than bone marrow stromal cells, the other type of mesenchymal stem cells which have been the target of intensive research. Canine DPCs constitutively expressed neural markers, suggesting a close relationship to the nervous system in their developmental origin. Canine DPCs promoted neuritogenesis of PC12 cells, most likely through secretion of neurotrophic factors. Furthermore, SPIO nanoparticles could be effectively transported to cDPCs without significant cytotoxicity and unfavorable effects on neuritogenesis. SPIO-labeled cDPCs embedded in agarose spinal cord phantoms were successfully visualized with a magnetic resonance imaging arousing a hope for noninvasive cell tracking in transplantation studies. |
| Starting Page | 1012 |
| Ending Page | 1022 |
| Page Count | 11 |
| File Format | |
| ISSN | 10712690 |
| Journal | In Vitro Cellular & Developmental Biology - Animal |
| Volume Number | 51 |
| Issue Number | 10 |
| e-ISSN | 1543706X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-07-14 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Dental pulp cells Mesenchymal stem cells Neurotrophic factors Neurite outgrowth Superparamagnetic iron oxide Cell Biology Developmental Biology Stem Cells Cell Culture Animal Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine |
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