NDLI: Biocompatibility of implantable electrodes coated with PVA films in the brain of rats: a histological evaluation

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Biocompatibility of implantable electrodes coated with PVA films in the brain of rats: a histological evaluation

Content Provider	Springer Nature Link
Author	Zhou, Qin Li, Tao Li, Chengyan Ye, Ming Lu, Yi Duan, Yanwen
Copyright Year	2009
Abstract	The biocompatibility of silicone rubber (SR) based electrodes coating with poly (vinyl alcohol) (PVA) films after implanted in the brain of rats was investigated. Twenty-two Wistar rats were used and implanted with SR electrodes and PVA/PAA films coated electrodes in left and right cerebral cortex respectively. After 4 and 8 weeks, the expression of glial fibrillary acidic protein (GFAP, a specific marker of astrocytes) and cluster of differentiation 68 (CD68, a specific marker of macrophages) were evaluated by immunohistochemistry. After 8 weeks, GFAP and CD68 expressions around PVA electrodes were significantly lower than those around SR electrodes in every stratified area (0–50 μm, 50–100 μm, 100 μm from further up to the electrode-tissue interface). The results show that PVA coating can reduce the expressions of GFAP and CD68, suggesting the PVA coating can improve the biocompatibility of the SR while it is implanted in brain.
Starting Page	393
Ending Page	396
Page Count	4
File Format	PDF
ISSN	10002413
Journal	Journal of Wuhan University of Technology-Mater. Sci. Ed.
Volume Number	24
Issue Number	3
e-ISSN	19930437
Language	English
Publisher	Wuhan University of Technology
Publisher Date	2009-07-09
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	biocompatibility poly(vinyl alcohol)(PVA) neural electrodes glial fibrillary acidic protein cluster of differentiation 68 Materials Science
Content Type	Text
Resource Type	Article
Subject	Materials Science

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