NDLI: Improved production of spiramycin by mutantStreptomyces ambofaciens

Content Provider	Springer Nature Link
Author	Zhi hua, Jin Pei lin, Cen
Copyright Year	2004
Abstract	Strain improvement and medium optimization to increase the productivity of spiramycin were carried out. Of oil tolerant mutant strains screened, one mutant,Streptomyces ambofaciens XC 2–37, produced 9% more spiramycin than the parent strainS. ambofaciens XC 1–29. The effects of soybean oil and propyl alcohol on spiramycin production withS. ambofaciens XC 2–37 were studied. The potency ofS. ambofaciens XC 2–37 was improved by 61.8% with addition of 2% soybean oil in the fermentation medium and 0.4% propyl alcohol at 24 hours after incubation. The suitable time for feeding propyl alcohol is at 24 hours after incubation in flask fermentation and at 20 hours after incubation in fermentor fermentation. The new process withS. ambofaciens XC 2–37 was scaled up for industrial scale production of spiramycin in a 60 m$^{3}$ fermentor in Xinchang Pharmaceutical Factory, Zhejiang Medicine Company, Ltd., China, and the potency and productivity of fermentation were improved by 42.9%.
Starting Page	689
Ending Page	695
Page Count	7
File Format	PDF
ISSN	1673565X
Journal	Journal of Zhejiang University SCIENCE A
Volume Number	5
Issue Number	6
e-ISSN	18621775
Language	English
Publisher	Zhejiang University Press
Publisher Date	2004-06-01
Publisher Place	Hangzhou
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Spiramycin Streptomyces ambofaciens Strain improvement Fermentation Mechanical Engineering Civil Engineering Classical Continuum Physics Industrial Chemistry/Chemical Engineering
Content Type	Text
Resource Type	Article
Subject	Engineering

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