NDLI: Down-regulated expression of aquaporin-4 in the cerebellum after status epilepticus

Content Provider	Springer Nature Link
Author	Tang, Hui Shao, Chuan He, Jiaquan
Copyright Year	2016
Abstract	Status epilepticus (SE) is a common neurological condition associated with high rates of mortality and permanent brain injury. SE usually leads to neuronal death which may be accompanied by edema, epileptogenesis and learning impairment. Aquaporin-4 (AQP4), is a transmembrane water channel protein in the neuropil of the central nervous system that has an important role in water transport in the brain; AQP4 expression is altered in many pathological conditions such as changes in the blood- brain barrier and/or astrocytic activation, including seizures. AQP4 was shown to be downregulated in the piriform cortex and the hippocampus after SE. Although it is normally expressed at a high level in the cerebellum, little is known about AQP4 levels in the cerebellum following SE. We addressed this in the present study in a mouse model of pilocarpine-induced SE. We found that AQP4 expression was reduced from 3 h to 3 days after SE, with the levels recovering on day 7. Moreover, mice in the acute post-SE stages exhibited impaired motor coordination and learning. These results indicate that cerebellar damage following SE involves changes in AQP4 expression.
Starting Page	183
Ending Page	188
Page Count	6
File Format	PDF
ISSN	18714080
Journal	Cognitive Neurodynamics
Volume Number	11
Issue Number	2
e-ISSN	18714099
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-11-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Status epilepticus Cerebellum Aquaporin-4 Edema Motor coordination Motor learning Biomedicine Neurosciences Computer Science Artificial Intelligence (incl. Robotics) Biochemistry Cognitive Psychology
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience

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