NDLI: The influence of ion concentrations on the dynamic behavior of the Hodgkin

Please wait, while we are loading the content...

The influence of ion concentrations on the dynamic behavior of the Hodgkin–Huxley model-based cortical network

Content Provider	Springer Nature Link
Author	Tagluk, M. Emin Tekin, Ramazan
Copyright Year	2014
Abstract	Action potentials (APs) in the form of very short pulses arise when the cell is excited by any internal or external stimulus exceeding the critical threshold of the membrane. During AP generation, the membrane potential completes its natural cycle through typical phases that can be formatted by ion channels, gates and ion concentrations, as well as the synaptic excitation rate. On the basis of the Hodgkin–Huxley cell model, a cortical network consistent with the real anatomic structure is realized with randomly interrelated small population of neurons to simulate a cerebral cortex segment. Using this model, we investigated the effects of Na$^{+}$ and K$^{+}$ ion concentrations on the outcome of this network in terms of regularity, phase locking, and synchronization. The results suggested that Na$^{+}$ concentration does slightly affect the amplitude but not considerably affects the other parameters specified by depolarization and repolarization. K$^{+}$ concentration significantly influences the form, regularity, and synchrony of the network-generated APs. No previous study dealing directly with the effects of both Na$^{+}$ and K$^{+}$ ion concentrations on regularity and synchronization of the simulated cortical network-generated APs, allowing for the comparison of results obtained using our methods, was encountered in the literature. The results, however, were consistent with those obtained through studies concerning resonance and synchronization from another perspective and with the information revealed through physiological and pharmacological experiments concerning changing ion concentrations or blocking ion channels. Our results demonstrated that the regularity and reliability of brain functions have a strong relationship with cellular ion concentrations, and suggested the management of the dynamic behavior of the cellular network with ion concentrations.
Starting Page	287
Ending Page	298
Page Count	12
File Format	PDF
ISSN	18714080
Journal	Cognitive Neurodynamics
Volume Number	8
Issue Number	4
e-ISSN	18714099
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-01-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cortical network Hodgkin–Huxley model Ion concentrations Dynamic behavior Regularity Synchronization Biomedicine general Neurosciences Computer Science Artificial Intelligence (incl. Robotics) Biochemistry Cognitive Psychology
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The influence of ion concentrations on the dynamic behavior of the Hodgkin-Huxley model-based cortical network.

A neural network model of attention-modulated neurodynamics

Noise-induced spatiotemporal patterns in Hodgkin–Huxley neuronal network

The influence of ion concentrations on the dynamic behavior of the Hodgkin–Huxley model-based cortical network

Oscillations and synchrony in a cortical neural network

Firing pattern and synchronization property analysis in a network model of the olfactory bulb

Outline of a novel architecture for cortical computation

The phase response of the cortical slow oscillation

Transient coordinated activity within the developing brain’s default network

The influence of ion concentrations on the dynamic behavior of the Hodgkin–Huxley model-based cortical network

Similar Documents

The influence of ion concentrations on the dynamic behavior of the Hodgkin-Huxley model-based cortical network.

A neural network model of attention-modulated neurodynamics

Noise-induced spatiotemporal patterns in Hodgkin–Huxley neuronal network

The influence of ion concentrations on the dynamic behavior of the Hodgkin–Huxley model-based cortical network

Oscillations and synchrony in a cortical neural network

Firing pattern and synchronization property analysis in a network model of the olfactory bulb

Outline of a novel architecture for cortical computation

The phase response of the cortical slow oscillation

Transient coordinated activity within the developing brain’s default network

The influence of ion concentrations on the dynamic behavior of the Hodgkin–Huxley model-based cortical network