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An ephaptic transmission model of CA3 pyramidal cells: an investigation into electric field effects

Content Provider	Springer Nature Link
Author	Wei, Xile Chen, Yinhong Lu, Meili Deng, Bin Yu, Haitao Wang, Jiang Che, Yanqiu Han, Chunxiao
Copyright Year	2013
Abstract	Extracellular electric fields existing throughout the living brain affect the neural coding and information processing via ephaptic transmission, independent of synapses. A two-compartment whole field effect model (WFEM) of pyramidal neurons embedded within a resistive array which simulates the extracellular medium i.e. ephapse is developed to study the effects of electric field on neuronal behaviors. We derive the two linearized filed effect models (LFEM-1 and LFEM-2) from WFEM at the stable resting state. Through matching these simplified models to the subthreshold membrane response in experiments of the resting pyramidal cells exposed to applied electric fields, we not only verify our proposed model’s validity but also found the key parameters which dominate subthreshold frequency response characteristic. Moreover, we find and give its underlying biophysical mechanism that the unsymmetrical properties of active ion channels results in the very different low-frequency response of somatic and dendritic compartments. Following, WFEM is used to investigate both direct-current (DC) and alternating-current field effect on the neural firing patterns by bifurcation analyses. We present that DC electric field could modulate neuronal excitability, with the positive field improving the excitability, the modest negative field suppressing the excitability, but interestingly, the larger negative field re-exciting the neuron back into spiking behavior. The neuron exposed to the sinusoidal electric field exhibits abundant firing patterns sensitive to the input frequency and intensity. In addition, the electrical properties of ephapse can modulate the efficacy of field effect. Our simulated results are qualitatively in line with the relevant experimental results and can explain some experimental phenomena. Furthermore, they are helpful to provide the predictions which can be tested in future experiments.
Starting Page	177
Ending Page	197
Page Count	21
File Format	PDF
ISSN	18714080
Journal	Cognitive Neurodynamics
Volume Number	8
Issue Number	3
e-ISSN	18714099
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-10-05
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Field effect Ephaptic transmission Subthreshold Extracellular electric field Firing pattern Biomedicine general Neurosciences Computer Science Artificial Intelligence (incl. Robotics) Biochemistry Cognitive Psychology
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience

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