NDLI: The effect of heterogeneously-distributed RyR channels on calcium dynamics in cardiac myocytes

Content Provider	Springer Nature Link
Author	Spiro, Peter A. Othmer, Hans G.
Copyright Year	1999
Abstract	Calcium plays an essential role in excitation-contraction coupling in muscle, and derangements in calcium handling can produce a variety of potentially harmful conditions, especially in cardiac muscle. In cardiac tissue specialized invaginations of the sarcolemma, called T-tubules, penetrate deep into each sarcomere, and depolarization of the SL leads to an influx of calcium through voltage-sensitive channels in the T-tubules that in turn triggers further calcium release from the sarcoplasmic reticulum via ryanodine-sensitive calcium channels. Under certain conditions, such as elevated external Ca$^{2+}$, cardiac cells can release calcium from the sarcoplasmic reticulum spontaneously, producing a calcium ’spark’ and propagating traveling waves of elevated Ca$^{2+}$ concentration, without depolarization of the SL (Wier and Blatter, 1991a, Cell Calcium 12, 241–254; Williams, 1993, Cell Calcium 14, 724–735; Cheng et al., 1993a, Science 262, 740–744). However, under normal resting conditions these potentially harmful waves seldom occur. In this paper we investigate the role of the periodic distribution of ryanodine-sensitive channels in determining whether a spark can trigger a wave, using a modification of the kinetic model proposed by Tang and Othmer, 1994b, Biophys. J. 67, 2223–2235, for calcium-induced calcium release. We show that the spatial localization of these channels near the T-tubules has a significant effect on both wave propagation and the onset of oscillations in this system. Spatial localization provides a possible explanation for the differing effects of various experimental protocols on the system’s ability to propagate a traveling wave.
Starting Page	651
Ending Page	681
Page Count	31
File Format	PDF
ISSN	00928240
Journal	Bulletin of Mathematical Biology
Volume Number	61
Issue Number	4
e-ISSN	15229602
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mathematical Biology in General
Content Type	Text
Resource Type	Article
Subject	Neuroscience Biochemistry, Genetics and Molecular Biology Mathematics Pharmacology Immunology Computational Theory and Mathematics Environmental Science Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A two-current model for the dynamics of cardiac membrane

A Model of CatSper Channel Mediated Calcium Dynamics in Mammalian Spermatozoa

Stability of cardiac waves

MODEL OF CALCIUM-INDUCED CALCIUM RELEASE MECHANISM IN CARDIAC CELLS

A Mathematical Model for Simultaneous Spatio-Temporal Dynamics of Calcium and Inositol 1,4,5-Trisphosphate in Madin–Darby Canine Kidney Epithelial Cells

Dynamics of the ‘echo’ effect in a phytoplankton system with nitrogen fixation

Homogenization of an Electrophysiological Model for a Strand of Cardiac Myocytes with Gap-Junctional and Electric-Field Coupling

Adaptive superparasitism and host-parasitoid dynamics

Iteroparous reproduction strategies and population dynamics

The effect of heterogeneously-distributed RyR channels on calcium dynamics in cardiac myocytes

Similar Documents

A two-current model for the dynamics of cardiac membrane

A Model of CatSper Channel Mediated Calcium Dynamics in Mammalian Spermatozoa

Stability of cardiac waves

MODEL OF CALCIUM-INDUCED CALCIUM RELEASE MECHANISM IN CARDIAC CELLS

A Mathematical Model for Simultaneous Spatio-Temporal Dynamics of Calcium and Inositol 1,4,5-Trisphosphate in Madin–Darby Canine Kidney Epithelial Cells

Dynamics of the ‘echo’ effect in a phytoplankton system with nitrogen fixation

Homogenization of an Electrophysiological Model for a Strand of Cardiac Myocytes with Gap-Junctional and Electric-Field Coupling

Adaptive superparasitism and host-parasitoid dynamics

Iteroparous reproduction strategies and population dynamics

The effect of heterogeneously-distributed RyR channels on calcium dynamics in cardiac myocytes