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| Content Provider | Springer Nature Link |
|---|---|
| Author | Sfakianakis, Nikolaos Kolbe, Niklas Hellmann, Nadja Lukáčová Medvid’ová, Mária |
| Copyright Year | 2016 |
| Abstract | We propose a multiscale model for the invasion of the extracellular matrix by two types of cancer cells, the differentiated cancer cells and the cancer stem cells. We investigate the epithelial mesenchymal-like transition between them being driven primarily by the epidermal growth factors. We moreover take into account the transdifferentiation program of the cancer stem cells towards the cancer-associated fibroblast cells as well as the fibroblast-driven remodelling of the extracellular matrix. The proposed haptotaxis model combines the macroscopic phenomenon of the invasion of the extracellular matrix by both types of cancer cells with the microscopic dynamics of the epidermal growth factors. We analyse our model in a component-wise manner and compare our findings with the literature. We investigate pathological situations regarding the epidermal growth factors and accordingly propose “mathematical-treatment” scenarios to control the aggressiveness of the tumour. |
| Starting Page | 209 |
| Ending Page | 235 |
| Page Count | 27 |
| File Format | |
| ISSN | 00928240 |
| Journal | Bulletin of Mathematical Biology |
| Volume Number | 79 |
| Issue Number | 1 |
| e-ISSN | 15229602 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-11-30 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cancer stem cell invasion Extracellular matrix Epidermal growth factor receptors Epithelial mesenchymal transition Mathematical and Computational Biology Life Sciences Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Biochemistry, Genetics and Molecular Biology Mathematics Pharmacology Immunology Computational Theory and Mathematics Environmental Science Agricultural and Biological Sciences |
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