NDLI: A novel approach for efficient extrication of overlapping chromosomes in automated karyotyping

Content Provider	Springer Nature Link
Author	Mut, Mousami V. Mukherjee, Jayanta Joshi, Madhuri
Copyright Year	2013
Abstract	Since the introduction of the automated karyotyping systems, segmentation and classification of touching and overlapping chromosomes in the metaphase images are major challenges. The earlier reported techniques for disentangling the chromosome overlaps have limited success and use only color information in case of multispectral imaging. Most of them are restricted to separation of single overlap of two chromosomes. This paper introduces a novel algorithm to extricate overlapping chromosomes in a metaphase image. The proposed technique uses Delaunay triangulation to automatically identify the number of overlaps in a cluster followed by the detection of the appropriate cut-points. The banding information on the overlapped region further resolves the set of overlapping chromosomes with the identified cut-points. The proposed algorithm has been tested with four data sets of 60 overlapping cases, obtained from publically available databases and private genetic labs. The experimental results provide an overall accuracy of 75–100 % for resolving the cluster of 1–6 overlaps.
Starting Page	1325
Ending Page	1338
Page Count	14
File Format	PDF
ISSN	01400118
Journal	Medical and Biological Engineering and Computing
Volume Number	51
Issue Number	12
e-ISSN	17410444
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-08-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Karyotyping Metaphase Chromosome Human Physiology Biomedical Engineering Imaging Radiology Computer Applications
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Computer Science Applications

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