NDLI: Advanced computational workflow for the multi-scale modeling of the bone metabolic processes

Content Provider	Springer Nature Link
Author	Dao, Tien Tuan
Copyright Year	2016
Abstract	Multi-scale modeling of the musculoskeletal system plays an essential role in the deep understanding of complex mechanisms underlying the biological phenomena and processes such as bone metabolic processes. Current multi-scale models suffer from the isolation of sub-models at each anatomical scale. The objective of this present work was to develop a new fully integrated computational workflow for simulating bone metabolic processes at multi-scale levels. Organ-level model employs multi-body dynamics to estimate body boundary and loading conditions from body kinematics. Tissue-level model uses finite element method to estimate the tissue deformation and mechanical loading under body loading conditions. Finally, cell-level model includes bone remodeling mechanism through an agent-based simulation under tissue loading. A case study on the bone remodeling process located on the human jaw was performed and presented. The developed multi-scale model of the human jaw was validated using the literature-based data at each anatomical level. Simulation outcomes fall within the literature-based ranges of values for estimated muscle force, tissue loading and cell dynamics during bone remodeling process. This study opens perspectives for accurately simulating bone metabolic processes using a fully integrated computational workflow leading to a better understanding of the musculoskeletal system function from multiple length scales as well as to provide new informative data for clinical decision support and industrial applications.
Starting Page	923
Ending Page	933
Page Count	11
File Format	PDF
ISSN	01400118
Journal	Medical and Biological Engineering and Computing
Volume Number	55
Issue Number	6
e-ISSN	17410444
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-09-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fully integrated computational workflow Multi-scale modeling Musculoskeletal system Rigid body modeling Finite element modeling Agent-based modeling Bone metabolic processes Bone remodeling Human Physiology Biomedical Engineering Imaging Radiology Computer Applications
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Computer Science Applications

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