NDLI: Modelling a parasystolic rhythm in a heart-transplant patient

Content Provider	Springer Nature Link
Author	Costa, M. Pimentel, I. R. Santiago, T. Rebocho, M. J. Melo, J. Ducla Soares, E.
Copyright Year	1999
Abstract	A parasystole from a heart-transplant patient is analysed using a beat-to-beat RR interval time series obtained from an electrocardiogram (ECG). The dysrhythmia, resulting from the co-existence of two pacemakers, the sinus node and an ectopic focus, presents distinctive regular patterns, with transitions from one pattern to another occurring abruptly. It is shown that the parasystolic rhythm can be simulated by a model involving two oscillators firing at fixed rates, under the restriction that neither is allowed to fire during the other's refractory period. It is found that the structure of the generated RR time series is essentially determined by the ratio of the periods of the two oscillators. In the case of a heart-transplant patient with a small heart-rate variability as a result of heart denervation, the model predicts the RR intervals with an error of less than 6% for an 80-beat sequence. From a physiological point of view, the results imply that the interaction between the two pacemakers in the heart is fairly weak, and hence the parasystole observed in the heart-transplant patient can be modelled as pure parasystole.
Starting Page	492
Ending Page	496
Page Count	5
File Format	PDF
ISSN	01400118
Journal	Medical and Biological Engineering and Computing
Volume Number	37
Issue Number	4
e-ISSN	17410444
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiac arrhythmia Parasystole Heart transplantion Heart dynamics Computer modelling Biomedical Engineering Human Physiology Imaging Radiology Computer Applications
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Computer Science Applications

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