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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, X. Bai, J. |
| Copyright Year | 2001 |
| Abstract | A baroregulation model, based on a previous pulsatile non-linear multielement cardiovascular model, is extended and used to study short-term regulation mechanisms. Using this model, the responses of several cardiovascular variables to different exercise levels are simulated and compared with the experimental data reported in the literature. The impact of physiological or pathological changes on the short-term regulation of arterial pressure under the stimulus of moderate dynamic exercise is then studied. The simulation results indicate that baroreflex feedback plays a critical role in the short-term regulation of arterial pressure. When the baroreflex gain decreases to one-third of the normal value, the response of the mean arterial pressure to moderate dynamic exercise and post-exercise recovery time increases by factors of 1.7 and 2.3, respectively. Clinical data from 36 subjects (two groups: normal and hypertensive) are collected to validate the model. Computer simulations for the hypertensive group show that the elastic modulus of the arterial vessel wall is increased by 1.5 times, and peripheral resistance is increased by 1.3 times the normal value, and the baroreflex gain decreases from 0.55 (for the normal group) to 0.40. The simulation results for normal and hypertensive groups agree well with the clinical data. |
| Starting Page | 480 |
| Ending Page | 487 |
| Page Count | 8 |
| File Format | |
| ISSN | 01400118 |
| Journal | Medical and Biological Engineering and Computing |
| Volume Number | 39 |
| Issue Number | 4 |
| e-ISSN | 17410444 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2001-01-01 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cardiovascular system Short-term regulation Baroregulation Autonomic nervous system Hypertension Human Physiology Computer Applications Neurosciences Imaging Radiology Biomedical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomedical Engineering Computer Science Applications |
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