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  1. Medical and Biological Engineering and Computing
  2. Medical and Biological Engineering and Computing : Volume 36
  3. Medical and Biological Engineering and Computing : Volume 36, Issue 6, November 1998
  4. Skin substitutes from cultured cells and collagen-GAG polymers
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Medical and Biological Engineering and Computing : Volume 55
Medical and Biological Engineering and Computing : Volume 54
Medical and Biological Engineering and Computing : Volume 53
Medical and Biological Engineering and Computing : Volume 52
Medical and Biological Engineering and Computing : Volume 51
Medical and Biological Engineering and Computing : Volume 50
Medical and Biological Engineering and Computing : Volume 49
Medical and Biological Engineering and Computing : Volume 48
Medical and Biological Engineering and Computing : Volume 47
Medical and Biological Engineering and Computing : Volume 46
Medical and Biological Engineering and Computing : Volume 45
Medical and Biological Engineering and Computing : Volume 44
Medical and Biological Engineering and Computing : Volume 43
Medical and Biological Engineering and Computing : Volume 42
Medical and Biological Engineering and Computing : Volume 41
Medical and Biological Engineering and Computing : Volume 40
Medical and Biological Engineering and Computing : Volume 39
Medical and Biological Engineering and Computing : Volume 38
Medical and Biological Engineering and Computing : Volume 37
Medical and Biological Engineering and Computing : Volume 36
Medical and Biological Engineering and Computing : Volume 36, Issue 6, November 1998
Volumetric analysis of CT orbital images
Automated sizing of DNA fragments in atomic force microscope images
Non-invasive temperature imaging of muscles with magnetic resonance imaging using spin-echo sequences
Roughness feature of metaphase chromosome spreads and nuclei for automated cell proliferation analysis
Three-dimensional biomechanical model for simulating the response of the human body to vibration stress
Implementation and application of real-time motion analysis based on passive markers
Development of a non-invasive treatment system for urinary incontinence using a functional continuous magnetic stimulator (FCMS)
The volume conductor may act as a temporal filter on the ECG and EEG
Neural network technique for detecting emergency states in neurosurgical patients
Fragmentation of bandpass-filtered QRS-complex of patients prone to malignant arrhythmia
Pressure measurements during injection of corticosteroids
Whole body urea kinetics
Multichannel laser-Doppler probe for blood perfusion measurements with depth discrimination
Non-invasive studies of peripheral vascular compliance using a non-occluding photoplethysmographic method
Staffieri tracheo-oesophageal prosthesis for voice rehabilitation after laryngectomy: an evaluation of characteristics
A wideband high common mode rejection ratio amplifier and phase-locked loop demodulator for multifrequency impedance measurement
Outlining the prostate boundary using the harmonics method
Use of diaphragm transducers in the measurement of pressures on soft materials
Special issue: Bioengineering of the skin : Editorial
Cultivation of human keratinocyte stem cells: current and future clinical applications
Skin substitutes from cultured cells and collagen-GAG polymers
Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: clinical and fundamental applications
Pigmented human skin equivalent—as a model of the mechanisms of control of cell-cell and cell-matrix interactions
Reconstructed human epidermis composed of keratinocytes, melanocytes and Langerhans cells
Applications of reconstructed skin models in pharmaco-toxicological trials
Medical and Biological Engineering and Computing : Volume 36, Issue 5, September 1998
Medical and Biological Engineering and Computing : Volume 36, Issue 4, July 1998
Medical and Biological Engineering and Computing : Volume 36, Issue 3, May 1998
Medical and Biological Engineering and Computing : Volume 36, Issue 2, March 1998
Medical and Biological Engineering and Computing : Volume 36, Issue 1, January 1998
Medical and Biological Engineering and Computing : Volume 35

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Skin substitutes from cultured cells and collagen-GAG polymers

Content Provider SpringerLink
Author Boyce, S. T.
Copyright Year 1998
Abstract Engineering skin substitutes provides a potential source of advanced therapies for the treatment of acute and chronic wounds. Cultured skin substitutes (CSS) consisting of human keratinocytes and fibroblasts attached to collagen-glycosaminoglycan substrates have been designed and tested in preclinical and clinical studies. Cell culture techniques follow general principles of primary culture and cryopreservation in liquid nitrogen for long-term storage. Biopolymer substrates are fabricated from xenogeneic (bovine) collagen and glycosaminoglycan that are lyophilised for storage until use. At maturity in air-exposed culture, CSS develop an epidermal barrier that is not statistically different from native human skin, as measured by, surface electrical capacitance. Preclinical studies in athymic miceshow rapid healing, expression of cytokines and regulation of pigmentation. Clinical studies in burn patients demonstrate a qualitative outcome with autologous skin that is not different from 1:4 meshed, split-thickness autograft skin, and with a quantitative advantage over autograft skin in the ratio of healed skin to biopsy areas. Chronic wounds resulting from diabetes or venous stasis have been closed successfully with allogeneic CSS prepared from cryopreserved skin cells. These results define the therapeutic benefits of cultured skin substitutes prepared with skin cells from the patient or from cadaver donors. Future directions include genetic modification of transplanted cells to improve wound healing transiently or to deliver gene products systemically.
Starting Page 791
Ending Page 800
Page Count 10
File Format PDF
ISSN 01400118
Journal Medical and Biological Engineering and Computing
Volume Number 36
Issue Number 6
e-ISSN 17410444
Language English
Publisher Kluwer Academic Publishers
Publisher Date 1998-01-01
Publisher Place Dordrecht
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Cultured skin substitutes Wound healing Keratinocytes Fibroblasts Biopolymers Human Physiology Neurosciences Imaging Radiology Computer Applications Biomedical Engineering
Content Type Text
Resource Type Article
Subject Biomedical Engineering Computer Science Applications
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