NDLI: Continuous arterio-venous haemodiafiltration: hydraulic and diffusive permeability index of an AN-69 capillary haemofilter

Content Provider	Springer Nature Link
Author	Akcahuseyin, E. Duyl, W. A. Vincent, H. H. Vos, M. C. Schalekamp, M. A. D. H.
Copyright Year	1998
Abstract	The dependence of uraemic solute clearance on the hydraulic and diffusive permeability index of an AN-69 capillary haemofilter is investigated during the treatment of patients with continuous arterio-venous haemodiafiltration (CAVHD). A mathematical model is presented to calculate solute clearance and the hydraulic and diffusive permeability index parameters from clinical data and to predict the blood flow rate entering the extra-corporeal circuit from the manufacturer's specifications and blood viscosity. By measuring the flow rates, the patient's mean arterio-venous pressure difference and uraemic solute clearance under different clinical and operational conditions, mathematical model equations are evaluated. During the average survival time of an AN-69 capillary haemofilter of about five days, it is found that both the hydraulic permeability index and the diffusive permeability index decline over treatment time, independent of the haemofilter resistance to blood flow. The measured haemofilter resistance to blood flow is three times higher than the haemofilter resistance predicted from the manufacturer's specifications and blood viscosity. Predicting the blood flow rate entering the extra-corporeal circuit from the arterial haematocrit, plasma protein concentration and temperature and the manufacturer's specifications is not reliable.
Starting Page	43
Ending Page	50
Page Count	8
File Format	PDF
ISSN	01400118
Journal	Medical and Biological Engineering and Computing
Volume Number	36
Issue Number	1
e-ISSN	17410444
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Continuous arterio-venous haemodiafiltration Dialysis Mass transfer Mathematical model Haemofilter performance Diffusive permeability Human Physiology Neurosciences Imaging Radiology Computer Applications Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Computer Science Applications

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