NDLI: Preparation, characterization, and antibacterial activity of oleic acid-grafted chitosan oligosaccharide nanoparticles

Content Provider	Springer Nature Link
Author	Huang, Lu Cheng, Xiaojie Liu, Chengsheng Xing, Ke Zhang, Jing Sun, Gangzheng Li, Xiaoyan Chen, Xiguang
Copyright Year	2009
Abstract	An oleic acid-grafted chitosan oligosaccharide (CSO-OA) with different degrees of amino substitution (DSs) was synthesized by the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-mediated coupling reaction. Fourier transform infrared spectroscopy (FT-IR) suggested the formation of an amide linkage between amino groups of chitosan oligosaccharide and carboxyl groups of oleic acid. The critical aggregation concentrations (CACs) of CSO-OA with 6%, 11%, and 21% DSs were 0.056, 0.042, and 0.028 mg·mL$^{−1}$, respectively. Nanoparticles prepared with the sonication method were characterized by means of transmission electron microscopy (TEM) and Zetasizer, and the antibacterial activity against Escherichia coli and Staphylococcus aureus was investigated. The results showed that the CSO-OA nanoparticles were in the range of 60–200 nm with satisfactory structural integrity. The particle size slightly decreased with the increase of DS of CSO-OA. The antibacterial trial showed that the nanoparticles had good antibacterial activity against E. coli and S. aureus.
Starting Page	321
Ending Page	327
Page Count	7
File Format	PDF
ISSN	16733509
Journal	Frontiers in Biology
Volume Number	4
Issue Number	3
e-ISSN	16733622
Language	English
Publisher	SP Higher Education Press
Publisher Date	2009-05-07
Publisher Institution	Chinese Universities
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	chitosan oligosaccharide nanoparticles antimicrobial activity Life Sciences
Content Type	Text
Resource Type	Article
Subject	Ecology Genetics Ecology, Evolution, Behavior and Systematics Biotechnology

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