NDLI: Solubility and Stability of β-Cyclodextrin–Terpineol Inclusion Complex as Affected by Water

Content Provider	Springer Nature Link
Author	Mazzobre, Maria Florencia Santos, Cristina Isabel Buera, Maria del Pilar
Copyright Year	2011
Abstract	In the present work, inclusion complexes of α-terpineol (Terp) and β-cyclodextrin (BCD) were prepared by the coprecipitation method. Phase solubility studies were performed and thermodynamic parameters involved in the complex formation were calculated. The solubility of Terp increased linearly as the concentration of BCD was increased, confirming the 1:1 stoichiometry of the complex. The stability constants decreased along with increasing temperature. The negative value of the enthalpy and of the Gibbs free energy demonstrated that the process is exothermic and spontaneous. Since complexation gives more ordered systems, the negative value obtained for the entropy change evidenced the encapsulation of Terp. Terp was completely encapsulated in BCD at the preparation conditions and studied molar ratios, as confirmed in the freeze-dried samples by differential scanning calorimeter. The presence of Terp greatly modified the BCD water sorption curves, and the amount of adsorbed water was lower for the complexes. The limited water solubility of Terp could be overcome by the formation of BCD inclusion complexes, and the complexes were stable at different storage conditions (relative humidities 11–97% and 25 °C). The obtained phase solubility data are useful for food or pharmaceutical products formulation involving cyclodextrins and stability predictions.
Starting Page	274
Ending Page	280
Page Count	7
File Format	PDF
ISSN	15571858
Journal	Food Biophysics
Volume Number	6
Issue Number	2
e-ISSN	15571866
Language	English
Publisher	Springer US
Publisher Date	2011-01-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Beta-cyclodextrin Terpineol Phase solubility studies Stability constant Freeze-dried complexes Analytical Chemistry Food Science Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Biophysics Bioengineering Food Science Applied Microbiology and Biotechnology

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