NDLI: Impact of Encapsulation Within Hydrogel Microspheres on Lipid Digestion: An In Vitro Study

Content Provider	Springer Nature Link
Author	Matalanis, Alison McClements, David Julian
Copyright Year	2012
Abstract	The objective of this study was to determine the influence of encapsulation of protein-coated lipid droplets within biopolymer hydrogel microspheres on their digestibility by lipase. We therefore compared the in vitro lipid digestion of non-encapsulated (“emulsions”) and encapsulated (“filled microspheres”) casein-coated lipid droplets. Filled microspheres were fabricated from a phase separated mixture of pectin and sodium caseinate and emulsified oil to form an oil-in-water-in-water (O/W/W) emulsion. The microspheres were then acidified, cross-linked with transglutaminase, and washed to remove excess pectin. Filled hydrogel microspheres were stable to simulated mouth conditions but formed large flocs under simulated gastric conditions. The casein stabilized emulsion showed modest droplet flocculation under simulated mouth conditions and showed significant flocculation and coalescence under simulated gastric conditions. The structure of both microspheres and emulsions was completely destroyed following in vitro digestion. Digestion profiles revealed similar rates of lipid digestion for both microspheres and emulsions. Since in vitro digestion conditions simulate the small intestine, the region of the body where the majority of lipid digestion and absorption occurs, these results suggest that lipid droplets encapsulated within microspheres would be digested similarly to those in conventional emulsions. Based on these findings, filled hydrogel microspheres appear to be a suitable delivery system for lipophilic bioactives.
Starting Page	145
Ending Page	154
Page Count	10
File Format	PDF
ISSN	15571858
Journal	Food Biophysics
Volume Number	7
Issue Number	2
e-ISSN	15571866
Language	English
Publisher	Springer US
Publisher Date	2012-04-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hydrogel particles Biopolymer particles Emulsions Delivery systems Transglutaminase In vitro digestion Biophysics and Biological Physics Analytical Chemistry Food Science
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Biophysics Bioengineering Food Science Applied Microbiology and Biotechnology

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