NDLI: HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

Content Provider	Springer Nature Link
Author	Lindl, Kathryn A. Marks, David R. Kolson, Dennis L. Jordan Sciutto, Kelly L.
Copyright Year	2010
Abstract	Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million people worldwide, and is associated with central nervous system (CNS) disruption in at least 30% of infected individuals. The use of highly active antiretroviral therapy has lessened the incidence, but not the prevalence of mild impairment of higher cognitive and cortical functions (HIV-associated neurocognitive disorders) as well as substantially reduced a more severe form dementia (HIV-associated dementia). Furthermore, improving neurological outcomes will require novel, adjunctive therapies that are targeted towards mechanisms of HIV-induced neurodegeneration. Identifying such molecular and pharmacological targets requires an understanding of the events preceding irreversible neuronal damage in the CNS, such as actions of neurotoxins (HIV proteins and cellular factors), disruption of ion channel properties, synaptic damage, and loss of adult neurogenesis. By considering the specific mechanisms and consequences of HIV neuropathogenesis, unified approaches for neuroprotection will likely emerge using a tailored, combined, and non-invasive approach.
Starting Page	294
Ending Page	309
Page Count	16
File Format	PDF
ISSN	15571890
Journal	Journal of Neuroimmune Pharmacology
Volume Number	5
Issue Number	3
e-ISSN	15571904
Language	English
Publisher	Springer US
Publisher Date	2010-04-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HIV HIV-associated neurocognitive disorder intranasal delivery chemokines oxidative stress excitotoxicity adult neurogenesis synaptic signaling cell cycle Cell Biology Virology Pharmacology/Toxicology Immunology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Allergy Pharmacology Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium

Host and Viral Factors Influencing the Pathogenesis of HIV-Associated Neurocognitive Disorders

Prefrontal Dopaminergic and Enkephalinergic Synaptic Accommodation in HIV-associated Neurocognitive Disorders and Encephalitis

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

Potential Roles of Microglial Cell Progranulin in HIV-Associated CNS Pathologies and Neurocognitive Impairment

Wnt Signaling in the Pathogenesis of Human HIV-Associated Pain Syndromes

Antioxidant Sestrin-2 Redistribution to Neuronal Soma in Human Immunodeficiency Virus-Associated Neurocognitive Disorders

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

Similar Documents

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium

Host and Viral Factors Influencing the Pathogenesis of HIV-Associated Neurocognitive Disorders

Prefrontal Dopaminergic and Enkephalinergic Synaptic Accommodation in HIV-associated Neurocognitive Disorders and Encephalitis

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

Potential Roles of Microglial Cell Progranulin in HIV-Associated CNS Pathologies and Neurocognitive Impairment

Wnt Signaling in the Pathogenesis of Human HIV-Associated Pain Syndromes

Antioxidant Sestrin-2 Redistribution to Neuronal Soma in Human Immunodeficiency Virus-Associated Neurocognitive Disorders

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities