NDLI: Opioids and Infections in the Intensive Care Unit Should Clinicians and Patients be Concerned?

Content Provider	Springer Nature Link
Author	Weinert, Craig R. Kethireddy, Shravan Roy, Sabita
Copyright Year	2008
Abstract	There is a large body of experimental evidence in research animals and in vitro models that opioids suppress the immune system. If this effect occurs in acute human disease, then patients cared for in Intensive Care Units (ICUs) would be a particularly vulnerable population. ICU patients have the most severe forms of acute infection, have the greatest risk of acquiring new infections in the hospital, and are exposed to high doses of opioids for long periods of time. We review the epidemiology of ICU infections and the pharmacoepidemiology of opioid use in critically ill patients. We critique the limited human research examining the relationship between opioids and infection and make recommendations on designing future clinical studies that could close the knowledge gap about the true hazards of opioid use in hospitalized patients.
Starting Page	218
Ending Page	229
Page Count	12
File Format	PDF
ISSN	15571890
Journal	Journal of Neuroimmune Pharmacology
Volume Number	3
Issue Number	4
e-ISSN	15571904
Language	English
Publisher	Springer US
Publisher Date	2008-09-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	opioids critical illness infection intensive care units immunosuppression artificial respiration Cell Biology Virology Pharmacology/Toxicology Immunology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Allergy Pharmacology Immunology

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