NDLI: NAD$^{+}$ and NADH in Neuronal Death

Content Provider	Springer Nature Link
Author	Ying, Weihai
Copyright Year	2007
Abstract	Neuronal death is a key pathological event in multiple neurological diseases. Increasing evidence has suggested that NAD$^{+}$ and NADH mediate not only energy metabolism and mitochondrial functions, but also calcium homeostasis, aging, and cell death. This article is written to provide an overview about the information suggesting significant roles of NAD$^{+}$ and NADH in neuronal death in certain neurological diseases. Our latest studies have suggested that intranasal administration with NAD$^{+}$ can profoundly decrease ischemic brain damage. These observations suggest that NAD$^{+}$ administration may be a novel therapeutic strategy for some neurological diseases.
Starting Page	270
Ending Page	275
Page Count	6
File Format	PDF
ISSN	15571890
Journal	Journal of Neuroimmune Pharmacology
Volume Number	2
Issue Number	3
e-ISSN	15571904
Language	English
Publisher	Springer US
Publisher Date	2007-02-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	NAD$^{+}$ NADH neuronal death brain injury cerebral ischemia neurodegenerative diseases Cell Biology Virology Pharmacology/Toxicology Immunology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Allergy Pharmacology Immunology

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NAD$^{+}$ and NADH in Neuronal Death