NDLI: Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function

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Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders

Epigenetic Regulation of Immunological Alterations Following Prenatal Exposure to Marijuana Cannabinoids and its Long Term Consequences in Offspring

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids

Cannabinoid Signaling and Neuroinflammatory Diseases: A Melting pot for the Regulation of Brain Immune Responses

Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids

Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials

Activation of Cannabinoid Type Two Receptors (CB$_{2}$) Diminish Inflammatory Responses in Macrophages and Brain Endothelium

A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways

A CB2-Selective Cannabinoid Suppresses T-Cell Activities and Increases Tregs and IL-10

Exposure to Δ9-Tetrahydrocannabinol Impairs the Differentiation of Human Monocyte-derived Dendritic Cells and their Capacity for T cell Activation

Modulation of HIV$_{GP120}$ Antigen-Specific Immune Responses In Vivo by Δ$^{9}$-Tetrahydrocannabinol

Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury

Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge

Exposure of Adolescent Mice to Delta-9-Tetrahydrocannabinol Induces Long-Lasting Modulation of Pro- and Anti-Inflammatory Cytokines in Hypothalamus and Hippocampus Similar to that Observed for Peripheral Macrophages

Psychiatric Symptoms, Salivary Cortisol and Cytokine Levels in Young Marijuana Users

Journal of Neuroimmune Pharmacology : Volume 10, Issue 2, Supplement,April 2015

Journal of Neuroimmune Pharmacology : Volume 10, Issue 1, Supplement,April 2015

Journal of Neuroimmune Pharmacology : Volume 10, Issue 1, March 2015

Journal of Neuroimmune Pharmacology : Volume 9

Journal of Neuroimmune Pharmacology : Volume 8

Journal of Neuroimmune Pharmacology : Volume 7

Journal of Neuroimmune Pharmacology : Volume 6

Journal of Neuroimmune Pharmacology : Volume 5

Journal of Neuroimmune Pharmacology : Volume 4

Journal of Neuroimmune Pharmacology : Volume 3

Journal of Neuroimmune Pharmacology : Volume 2

Journal of Neuroimmune Pharmacology : Volume 1

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function

Content Provider	Springer Nature Link
Author	Cabral, Guy A. Rogers, Thomas J. Lichtman, Aron H.
Copyright Year	2015
Abstract	Cannabis is a complex substance that harbors terpenoid-like compounds referred to as phytocannabinoids. The major psychoactive phytocannabinoid found in cannabis ∆$^{9}$-tetrahydrocannabinol (THC) produces the majority of its pharmacological effects through two cannabinoid receptors, termed CB$_{1}$ and CB$_{2}$. The discovery of these receptors as linked functionally to distinct biological effects of THC, and the subsequent development of synthetic cannabinoids, precipitated discovery of the endogenous cannabinoid (or endocannabinoid) system. This system consists of the endogenous lipid ligands N- arachidonoylethanolamine (anandamide; AEA) and 2-arachidonylglycerol (2-AG), their biosynthetic and degradative enzymes, and the CB$_{1}$ and CB$_{2}$ receptors that they activate. Endocannabinoids have been identified in immune cells such as monocytes, macrophages, basophils, lymphocytes, and dendritic cells and are believed to be enzymatically produced and released “on demand” in a similar fashion as the eicosanoids. It is now recognized that other phytocannabinoids such as cannabidiol (CBD) and cannabinol (CBN) can alter the functional activities of the immune system. This special edition of the Journal of Neuroimmune Pharmacology (JNIP) presents a collection of cutting edge original research and review articles on the medical implications of phytocannabinoids and the endocannabinoid system. The goal of this special edition is to provide an unbiased assessment of the state of research related to this topic from leading researchers in the field. The potential untoward effects as well as beneficial uses of marijuana, its phytocannabinoid composition, and synthesized cannabinoid analogs are discussed. In addition, the role of the endocannabinoid system and approaches to its manipulation to treat select human disease processes are addressed.
Starting Page	193
Ending Page	203
Page Count	11
File Format	PDF
ISSN	15571890
Journal	Journal of Neuroimmune Pharmacology
Volume Number	10
Issue Number	2
e-ISSN	15571904
Language	English
Publisher	Springer US
Publisher Date	2015-06-09
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cannabinoids Cannabinoid receptors Endocannabinoids Immune modulation Neuroimmune effects Marijuana Phytocannabinoids Neurosciences Immunology Pharmacology/Toxicology Virology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Allergy Pharmacology Immunology

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Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function

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Epigenetic Regulation of Immunological Alterations Following Prenatal Exposure to Marijuana Cannabinoids and its Long Term Consequences in Offspring

Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function

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