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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ramadan, Epolia Basselin, Mireille Chang, Lisa Chen, Mei Ma, Kaizong Rapoport, Stanley I. |
| Copyright Year | 2012 |
| Abstract | HIV-1 transgenic (Tg) rats, a model for human HIV-1 associated neurocognitive disorder (HAND), show upregulated markers of brain arachidonic acid (AA) metabolism with neuroinflammation after 7 months of age. Since lithium decreases AA metabolism in a rat lipopolysaccharide model of neuroinflammation, and may be useful in HAND, we hypothesized that lithium would dampen upregulated brain AA metabolism in HIV-1 Tg rats. Regional brain AA incorporation coefficients k* and rates J $_{ in }$, markers of AA signaling and metabolism, were measured in 81 brain regions using quantitative autoradiography, after intravenous [1-$^{14}$ C]AA infusion in unanesthetized 10-month-old HIV-1 Tg and age-matched wildtype rats that had been fed a control or LiCl diet for 6 weeks. k* and J $_{ in }$ for AA were significantly higher in HIV-1 Tg than wildtype rats fed the control diet. Lithium feeding reduced plasma unesterified AA concentration in both groups and J $_{ in }$ in wildtype rats, and blocked increments in k* (19 of 54 regions) and J $_{ in }$ (77 of 81 regions) in HIV-1 Tg rats. These in vivo neuroimaging data indicate that lithium treatment dampened upregulated brain AA metabolism in HIV-1 Tg rats. Lithium may improve cognitive dysfunction and be neuroprotective in HIV-1 patients with HAND through a comparable effect. |
| Starting Page | 701 |
| Ending Page | 713 |
| Page Count | 13 |
| File Format | |
| ISSN | 15571890 |
| Journal | Journal of Neuroimmune Pharmacology |
| Volume Number | 7 |
| Issue Number | 3 |
| e-ISSN | 15571904 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-07-04 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | HIV-1 Lithium Arachidonic acid Brain imaging Phospholipase A$_{2}$ Metabolism Immunology Pharmacology/Toxicology Neurosciences Virology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Immunology and Allergy Pharmacology Immunology |
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