NDLI: Localized Surface Plasmon Resonance-Based Fiber Optic U-Shaped Biosensor for the Detection of Blood Glucose

Content Provider	Springer Nature Link
Author	Srivastava, Sachin K. Arora, Vikas Sapra, Sameer Gupta, Banshi D.
Copyright Year	2011
Abstract	In the present study, we report the first fiber optic glucose sensor utilizing localized surface plasmon resonance of metal nanoparticles. The fiber was bent in the form of a U-shaped probe for point detection and sensitivity enhancement. The probe was prepared by first attaching gold nanoparticles on the optical fiber core and then immobilizing glucose oxidase over it. The sensor operates in the intensity modulation scheme in which the absorbance is measured with respect to the changes in the glucose concentration. The presence of glucose in the vicinity of the sensing region changes the refractive index of the film due to the chemical reactions with glucose oxidase. The absorbance of the metal nanoparticle changes significantly due to local refractive index change. The fiber optic U-shaped probes of different bending radii were fabricated and it has been found that the probe with bending radius around 0.982 mm possesses the maximum sensitivity. The response of the sensor is fast and requires very small volume of sensing sample (∼150 μl) which makes it more suitable for commercialization and better than present commercial sensors, which require about 1.5 ml of blood for the detection of glucose.
Starting Page	261
Ending Page	268
Page Count	8
File Format	PDF
ISSN	15571955
Journal	Plasmonics
Volume Number	7
Issue Number	2
e-ISSN	15571963
Language	English
Publisher	Springer US
Publisher Date	2011-11-09
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Surface plasmon Nanoparticles Optical fiber Sensor Glucose Biochemistry Biotechnology Nanotechnology Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Biochemistry Biophysics Biotechnology

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