NDLI: Spectrophotometric determination of β-adrenergic antagonists drugs via ion-pair complex formation using MO and EBT

Content Provider	Springer Nature Link
Author	El Didamony, A. M. Shehata, A. M.
Copyright Year	2014
Abstract	Two simple, rapid and sensitive spectrophotometric methods have been proposed for the assay of bisoprolol fumarate (BSF), propranolol hydrochloride (PRH), and timolol maleate (TIM) either in bulk or in pharmaceutical formulations. The methods are based on the reaction of the selected drugs with methyl orange (MO) and eriochrome black T in acidic buffers, after extracting in dichloromethane and measured quantitatively with maximum absorption at 428 and 518 nm for MO and EBT, respectively. The analytical parameters and their effects on the reported systems are investigated. The extracts are intensely colored and very stable at room temperature. The calibration graphs were linear over the concentration range of 0.8–6.4, 0.4–3.6, 0.8–5.6 μg/mL for BSF, PRH, and TIM, respectively, with MO and 0.8–6.4, 0.4–3.2, and 0.8–8.0 μg/mL for BSF, PRH, and TIM, respectively, with EBT. The stoichiometry of the complexes was found to be 1 : 1 in all cases. The proposed methods were successfully extended to pharmaceutical preparations. Excipients used as additive in commercial formulations did not interfere in the analysis. The proposed methods can be recommended for quality control and routine analysis where time, cost effectiveness and high specificity of analytical technique are of great importance.
Starting Page	492
Ending Page	499
Page Count	8
File Format	PDF
ISSN	0030400X
Journal	Optics and Spectroscopy
Volume Number	117
Issue Number	3
e-ISSN	15626911
Language	English
Publisher	Pleiades Publishing
Publisher Date	2014-09-23
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics Electronic, Optical and Magnetic Materials

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