NDLI: Composition of titin isoforms of skeletal and cardiac muscles in pathologies

Content Provider	Springer Nature Link
Author	Vikhlyantsev, I. M. Podlubnaya, Z. A.
Copyright Year	2008
Abstract	An electophoretic study of changes in composition of titin isoforms in human and rat skeletal and cardiac muscles is carried out. A more considerable decrease in the content of intact titin isoforms was observed than in the content of N2A-titin in the dorsal muscle of patients with the “stiff-person syndrome” and in m. soleus of humans and rats during development of “muscle hypogravity syndrome” and than in the content of N2BA- and N2B-titins in hypertrophic heart of spontaneously hypertensive rats. The relation between reduction of titin content in m. soleus and the increase of time the rats were in conditions of simulated microgravity is revealed. On electrophoregrams of left ventricle myocardium of patients with terminal stage of dilated cardiomyopathy the intact titin and N2BA-titin were absent and a considerable decrease in the content of N2B-titin was observed. This could be the consequence of the terminal stage of pathology. It follows that development of the diseases is accompanied by a greater destruction of intact titin than of its other forms which may be important for diagnostics of pathological processes.
Starting Page	592
Ending Page	597
Page Count	6
File Format	PDF
ISSN	00063509
Journal	Biophysics
Volume Number	53
Issue Number	6
e-ISSN	15556654
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2009-03-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	intact titin isoforms N2B- N2BA- N2A-titins titin fragments dilated cardiomyopathy “stiff-man syndrome” cardiac hypertrophy “muscle microgravity syndrome” Biophysics/Biomedical Physics
Content Type	Text
Resource Type	Article
Subject	Biophysics

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