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The effects of antioxidants and hypohalous acid scavengers on neutrophil activation by hypochlorous acid-modified low-density lipoproteins

Content Provider	Springer Nature Link
Author	Panasenko, O. M. Mikhalchik, E. V. Gorudko, I. V. Grigorieva, D. V. Sokolov, A. V. Kostevich, V. A. Vasilyev, V. B. Cherenkevich, S. N.
Copyright Year	2016
Abstract	Hypochlorous acid-modified human blood low density lipoprotein (LDL–HOCl) was shown to stimulate neutrophils and to increase the luminol- (lm-CL) or lucigenin-enhanced chemiluminescence (lc-CL) of neutrophils. Antioxidants and HOCl scavengers (glutathione, taurine, cysteine, methionine, ceruloplasmin, and human serum albumin (HSA)) were tested for effects on lm-CL, lc-CL, H$_{2}$O$_{2}$ production, and degranulation of azurophilic granules of neutrophils. All agents used in increasing concentrations were found to decrease lm-CL produced by neutrophils upon stimulation with LDL–HOCl or subsequent treatment with the activator phorbol 12-myristate 13-acetate (PMA). The agents exerted a far lower, if any, effect on lc-CL and the H$_{2}$O$_{2}$ production by neutrophils in the same conditions. In the majority of cases, a decline in neutrophil chemiluminescence in the presence of the agents was not related to their effect on neutrophil degranulation, but was most likely due to their direct interactions with reactive halogen (RHS) or oxygen (ROS) species generated upon neutrophil activation or to myeloperoxidase (MPO) inhibition. Antioxidants and HOCl scavengers present in the human body were assumed to decelerate the development of oxidative or halogenative stress and thereby prevent neutrophil activation.
Starting Page	420
Ending Page	428
Page Count	9
File Format	PDF
ISSN	00063509
Journal	Biophysics
Volume Number	61
Issue Number	3
e-ISSN	15556654
Language	English
Publisher	Pleiades Publishing
Publisher Date	2016-08-16
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	halogenative stress oxidative stress low density lipoprotein neutrophil activation reactive halogen species chemiluminescence Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Biophysics

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