NDLI: Effects of nifedipine on the mechanical properties of sarcolemma and modulation of dynamics of the increase in the basal calcium level in fibers of rat soleus muscle under short-term hypogravity conditions

Content Provider	Springer Nature Link
Author	Ogneva, I. V. Altaeva, E. G.
Copyright Year	2010
Abstract	It has been shown that the modulation of the mechanical properties of sarcolemma mediated by nifedipine may be related to the dynamics of accumulation of calcium ions under short-term rat hindlimb suspension. The basal calcium level was measured with a fluorescent probe Fluo-4AM, the transverse stiffness of different parts of the contractile apparatus and sarcolemma was estimated by atomic force microscopy, and the content of desmin was determined by gel electrophoresis with immunoblotting. It has been found that nifedipine has a protective effect on muscle fibers under hypogravity by decreasing the degradation of desmin and proteins that determine the transverse stiffness of sarcolemma and the contractile apparatus, and the intensity of the increase in the basal calcium level. It was shown that selective blocking of L-channels leads to an increase in the basal calcium level in intact soleus fibers. At the same time, the transverse stiffness of sarcolemma and the contractile apparatus increases. The mechanism of this increase is still unclear, but it is thought to mediate the protective action of nifedipine.
Starting Page	807
Ending Page	811
Page Count	5
File Format	PDF
ISSN	00063509
Journal	Biophysics
Volume Number	55
Issue Number	5
e-ISSN	15556654
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2011-02-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	gravitational unloading soleus muscle transversal stiffness desmin basal calcium level nifedipine Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Biophysics

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